(09-08-2014, 01:02 AM)Tanya Marie Squirrel Wrote: thanks lotus, i will definately look at those. what i have been running into is a lot of conrtadicting information. some are saying it is an anti androgen, some merely an adaptogen and some say it does not effect T levels at all....ran into the same thing with white peony when i was doing independent research on that herb after i heard it only effected women as an anti-androgen, found some sites that confirmed that and then again,some sites that outright said it was an anti-androgen....it gets very frustrating, who is telling the truth?
Squirrel, you might try parsing that last paragraph you pasted from the rawforestfood blog to get an idea if you should believe ANYTHING they post. There is only one sentence in that paragraph that is correct (that androgen induced cell growth can result in BPH and prostate CA).
First, 5-AR isn't a class of compounds. It is an enzyme that catalyzes the conversion T to DHT.
Second, 5-AR isn't found in red reishi. If it was found in red reishi, it would have the opposite effect in that it would PROMOTE conversion of T to DHT.
Third, 5-AR does NOT bind to androgen receptors. It binds to free T and converts it to DHT.
Fourth, as the links Lotus provided will tell you, red reishi significantly inhibits 5-AR activity thereby reducing the conversion of T to DHT. That is the mechanism of action as an AA and the MAIN REASON it is beneficial for prostate health.
Except for the last (4th) point above, you already know this stuff. If they are getting such basic physiology wrong, I would be pretty suspicious off anything else they have to say.
Also, in the second paragraph they say red reishi doesn't reduce T and in some cases will actually increase free T (correct) but attribute its mysterious AA properties to being an adaptogen. That's herbalist BS and basically says they don't know what they're talking about. It increases free T because less free T is converted to DHT. It's simple biochemistry. Given their lack of basic understanding in the next paragraph, you might be inclined to give them a pass on this one, but I wouldn't. Red reishi likely has other properties that can be described as adaptogenic (
As a pharmacotherapeutic group, adaptogens were recently defined as herbal preparations that increased attention and endur- ance in fatigue, and reduced stress-induced impairments and disor- ders related to the neuro-endocrine and immune systems...Today, the term adaptogen is widely used by many herbalists although it has yet to gain prominence in mainstream pharmacology. https://www.researchgate.net/profile/Alexander_Panossian2/publication/236462312_Adaptogens_A_Review_of_their_History_Biological_Activity_and_Clinical_Benefits/links/0c96052173fa37ab59000000.pdf) but it's AA properties don't fit that description.