(05-12-2015, 12:35 AM)Tanya Marie Squirrel Wrote: (05-12-2015, 12:32 AM)bobowo Wrote: (04-12-2015, 11:43 PM)Lotus Wrote: (04-12-2015, 11:25 PM)myboobs Wrote: This dumb fuffer's brain stopped working after reading one paragraph [/i]
Muther fluffin fuff myboobs ........j/k how about this?.
The DHT in ur nut sac can be made into estrogen without a big fuss. We can also reduce DHT in the prostate, reduce BPH and cancer by this second (newer estrogen) made from a side effect of DHT in the prostate and testes. Hopefully, this new process eliminates some of the supplements and lessens the strain on the liver, by all the NBE products. Not convinced?..........that crazy science mumbo jumbo I just listed says otherwise.
Could you summarize the supplements or procedure as to actually get your "DHT in ur nut sac [to be] made into estrogen" ? It looked like you first mentioned cortisol, so basically stress yourself out? Thanks!
If thats the case....no wonder transgender women are beautiful.....we stress over alot...thats alot of free flowing E in our veins.
Yes, stress makes you beautiful lol, wait what?. Isn't that typical though, one hormone gain means dealing with it's side effect and might impact the benefits of other hormones. However in this case cortisol has a direct effect on ER-b (estrogen receptor beta) in the prostrate and testes, HSD 11 beta type 1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors, in that instance it (glucocorticoid receptors) helps with boob growth, which we have in boobs, about 20% (glucocorticoid receptors). Licorice and green tea reduce 11 beta HSD type 1. I believe Leptin does the same though. Soooo....following the science I colored highlighted the two key points of interest. As you read this process could go either way, imo if you suppress DHT it will upregulate estrogen to activate E1 to E2 the active form of estrogen (Estradiol), which is what feminizes. I do suggest (even with Hrt) you at least normalize the androgen production in the testes 1-2 times a month. The amino acids L-arginine, Tuarine, Tyrosine all helps in this new process, I will explain about those too.
Sex steroids and leptin regulate 11β-hydroxysteroid dehydrogenase I and P450 aromatase expressions in human preadipocytes: Sex specificities
Service de Biochimie et de Biologie Moléculaire, UPRES EA 2493, Faculté de Médecine Paris-Ile de France-Ouest, Université Versailles St Quentin, Centre Hospitalier de Poissy, 78303 Poissy Cedex, France.
The Journal of Steroid Biochemistry and Molecular Biology (Impact Factor: 3.63). 07/2006; 99(4-5):189-96. DOI: 10.1016/j.jsbmb.2006.01.007
Source: PubMed
ABSTRACT
Adipose tissue is an important site of steroid hormone biosynthesis, as type I 11beta-hydroxysteroid dehydrogenase (HSD1), the enzyme responsible for the conversion of cortisone into cortisol and the P450 aromatase,
the enzyme catalysing androgens aromatization into estrogens, are both expressed in human adipose tissue. In the present report, we have investigated the possibility that sex steroids and leptin could regulate these two enzymes in cultured preadipocytes from men and women intra-abdominal fat depots. In women preadipocytes, human recombinant leptin down-regulates HSD1 mRNA expression (-58%) and P450 aromatase activity (-26%).
Conversely, leptin up-regulates the HSD1 (2.4-fold) and the P450 aromatase (1.6-fold) mRNA expression in men preadipocytes. In women preadipocytes, 17beta-estradiol strongly stimulates HSD1 mRNA expression (10-fold) and, in contrast, decreases by half the P450 aromatase expression. In men, 17beta-estradiol has no influence on HSD1 expression but up-regulates P450 aromatase mRNA expression (2.4-fold). Finally, androgens increase by a factor of 2.5-5 the mRNA expression of both enzymes in men. These findings suggest that sex steroids and leptin either increase or decrease local cortisol and estrogens productions in men or in women preadipocytes, respectively. They also indicate that steroid metabolism in adipose tissue is controlled by a coordinated regulation of P450 aromatase and HSD1 expressions. Finally, the important sex-specific differences described herein may also contribute to explain the sexual dimorphism of body fat distribution in humans.
I'll post more info tomorrow (hopefully) have a good night.