I'd run this past Lara, as I know she supplements her HRT with low-dose BO. I believe Lotus recently made a positive mention of doing the same. BioLabs Bi-Est 5.0 is the recommended cream to use, though.

I'm one of the users who in the past got in trouble with combining BO with PM when I stupidly was taking both products at a max dosage. It put me in the hospital with a mini-stroke.

I then ceased both products for two months and then started back on PM at a much more reasonable and normal dose. That was 6-7 years ago.

Yes I looked at the ingredients, and it doesn't say p.m but I'm not sure if the ingredients in it act in the same way and use the same path ways as p.m ( if that makes sense) 

I know both Lara and lotus have mentioned about supporting HRT with nbe as well. But like everyone knows it's not an exact science. And I feel they were really far a long with their growth and transformation before they started HRT. So keeping nbe and hrt at the same time I would assume didn't have any negative effects or that it didn't interfere with the HRT or their labs to get them where their HRT doses needed to be.

We're as I am coming from a place of high testosterone levels which have been high for many years. In trying to reset my body back to normal (or what ever it's new normal will be) I also have not been using NBE for very long and have yet to see any growth.  So I'm not sure if what they're doing is good for someone that is not as far along as them. It may be great for them and individuals who have been using NBE for awhile and have had good success and want more and decide to use hrt as well, or for those that have been on HRT and decided that a little extra supportive supplements couldn't hurt their transition. Again I'm not sure what the best route or advice would be for a beginner who has not been on nbe longer than a month max on p.m and only a week and half on Bo with no breast growth what so ever. 

Not sure if I'm able to get what I'm thinking across accurately. Hopefully that makes sense. 

But I guess if I am that worried about it I should get off everything and let my body do what ever it does naturally till I am able to get on HRT first and run that for 3-6 months before things become more permanent if hrt is continued to be used longer. 

I know many people say that everyone transition is different. Some may take hormones for a month or so to see how they feel on them so may take them for longer and then stop and start up many times. And the last thing is want to do is mess up my bodies balance before I get to see an endocrinologist. But at the same time I don't want to not do anything at all either.

Supplementing topicals with orally taken NBE is totally fine. Supplementing bovine ovary with other hormonal stuffs is totally fine. They will not magically cancel each other out or something. What comes to topicals, it seems that these ingredients are working in concert rather than against each other. Currently, I'm doing quite a mix that I apply topically. It has P4, E1, E2, Bovine Ovary(Yes, topically.) Cayenne extract, Cinnamon leaf oil, Volufiline, Micronised DHEA and DSMO cream. That's quite a bunch of stuff and they work like magic when done together.

What I would stay clear off is certain phytoestrogens though. Note that NONE of the above contain phytoestrogen. All come with bioidentical hormones or they mimic it. Also, I'm taking bovine ovary, pituitary and uterine glandulars along with conventional HRT. Also amino acids which deal with HGH and then some things for prolactin. Again, these do not interfere with HRT or cause stalls or anything. Can we already drop the receptor conflict scare?

It does happen, but not with everything and anything, Lotus is far more knowledgeable about receptor conflicts and how it all works than I am, my experience is mostly based on throwing stuff at a wall and seeing what sticks, but so far I've never had any mentionable receptor conflict issue, I have only avoided phyto estrogens along with HRT and bovine ovary.

So what comes to topical hormones, I wouldn't be too worried about combining them with other NBE items nor with HRT. People are always scared shitless with "don't combine things", but that's mostly a baseless fear. Just play it smart, especially along with the phytoestrogen route. But BO + topicals is totally fine.

Lara, thanks you. That puts my mind at ease with using both the enhance cream and the bio est 5.0 at the same time with b.o routine.

Is there a recommendation on dosage for the bio est 5.0 cream/location. Directions says 1 pump a day or more based on a physicians recommendations. Each pump is 5mg of E. 

Everything I've seen online for Rx strength topical gels suggest 4-10mg per day. I would assume that since this is over the counter that it is obviously not as strong as the Rx topical gels or patches. 

What is everyone else doing for dosage on the bio est 5.0 topical location?

Is there a recommendation on dose for the bio est 5.0 cream/location. Directions says 1 pump a day or more based on a physicians recommendations. Each pump is 5mg of E. 

Everything I've seen online for Rx strength topical gels suggest 2-4mg per day. I would assume that since this is over the counter that it is obviously not as strong as the Rx topical gels or patches. 

What is everyone else doing for dosage on the bio est 5.0 topical location?

Is there a recommendation on dose for the bio est 5.0 cream/location. Directions says 1 pump a day or more based on a physicians recommendations. Each pump is 5mg of E. 

Everything I've seen online for Rx strength topical gels suggest 2-4mg per day. I would assume that since this is over the counter that it is obviously not as strong as the Rx topical gels or patches. 

What is everyone else doing for dosage on the bio est 5.0 topical location?

I am very interested in this as well, but would like to know the difference in application for:
1.  Just nipple and areola growth.
2.  Overall breast growth.

Is there a recommendation on dose for the bio est 5.0 cream/location.

I found this in the Project-X thread ....

https://www.breastnexum.com/showthread.php?tid=17436&pid=214482#pid214482

Remember, if you have any questions about NBE/HRT, then chances are that Lotus has already covered it.

Just do a keyword search in the Project-X thread. At the bottom of the page in each thread, but more specifically the Project-X thread, there is a keyword search function for that thread.

Is there a recommendation on dose for the bio est 5.0 cream/location. Directions says 1 pump a day or more based on a physicians recommendations. Each pump is 5mg of E. 

Everything I've seen online for Rx strength topical gels suggest 2-4mg per day. I would assume that since this is over the counter that it is obviously not as strong as the Rx topical gels or patches. 

What is everyone else doing for dosage on the bio est 5.0 topical location? 

The dose is one pump per day, as in the instructions. 5mg is 5mg.
For Bi-Est 5.0 that is 4.0mg Estriol and 1.0mg Estradiol.

The scrotum is the most absorptive and effective area of application for overall feminization, but you can put it anywhere, preferably on thin skin.

Karen 

So two pumps a day is too much. Lol I'll have to back it back down to one a day. Lol.