Hi Jennifer,

Just popped in to see whats going on and seen this post, please forgive me if I you already know this, months ago I watched a video by a now deseased transgender woman, she explained in great detail about transition. (she was killed in a farming accident, she was driving a tractor on her farm when it over turned)

She says that without Anti-androgen getting results is difficult and will take a long time, it will always be costly so when I started this I took anti-androgen, over the weekend I will put a link on the site for you to watch, it is a short video and hope it helps.

As a matter of interest, Q. You look great and I am envious so what is it you want to achieve? just asking, I may not understand so I wait with keen interest your reply.

Liz
x

Hello Liz

My translations may not be correct.
What I mean is that until I have an anti-androgen, I have to take a lot of other things to lower my testosterone.

Jennifer.


And so yes I know that it is better to have an anti-androgen for the transformation to be effective and to do what, well my time, 
to be what I see in my head, what I have felt since I was thirty.
I did like many here, I got married, I had a daughter (soon to be 23), my ex discovered my "special" as I call it, we divorced, and now I'm trying to to be what I am.
I don't know if I answered what you expect from my answer.

Kisses Liz.

Jennifer.

This is not the thread either, to ask me such a question.
You have my email

The estradiol level is good.
And the testosterone level too.
Only, to reach this level of testosterone, I take:
The morning:
Dim, D3, RR, EGCg, MSM

You're estradiol looks good, and you're halfway there in suppressing testosterone @ 1.735 nmol/L (goal)

[moderator notice - unnecessary quoting removed]




You're estradiol looks good, and you're halfway there in suppressing testosterone @ 1.735 nmol/L (goal)
[/quote]

And what else can I do or take to further lower my testosterone level.

My goal is to get a real anti-androgen from my doctor.

And for the moment it's gone badly given that I did not follow what she asked me (to stop all other products).

Do you have links to sites for anti-androgen products?
In order to show my doctor my determination to take anti-androgens whether with a prescription or by myself on the net.

Thanks for your help, or any other member.

Kisses

Jennifer

@Lotus

I'm so impressed with your biology and endocrine knowledge, I can tell this forum really benefits from all your hard work.

I was wondering if you could pretty please comment on my blood tests from over a year ago? The test was conducted before I played with NBE, and I was suffering from low libido and erectile issues.

I can remove this post if that's not something you'd be interesting in doing. The endo says it's secondary hypogonadism, so I've been given testosterone gels. I'm using them, but I have since started taking PM tablets and used PM cream. I want sensitive nipples but no so much the growth (except when I'm horny, then would love to have some growth and buds and puffy ones).

I've been using very large amounts of Pygeum (for the pre-cum vitamin stack) and I think that's affected my libido and lowered my DHT, although the DHT result seems mid-range. Pygeum is supposedly a 5-aR inhibitor, which I found out some time after taking very large amounts (3000mg to 15000mg per day sometimes).

Anyway if you would be happy to comment? Lets say I'm 35 and obese.

DHT: 0.57 nmol/L (0.32 to 1.64)
LH: 4.6 U/L (1.7 to 8.6)
Estradiol: 70 pmol/L (41 to 159) (a more recent blood test, 5 months ago, was 96)
Total Testosterone: 3.9 nmol/L (8 to 30) Below range
Free testosterone: 5.4 pg/mL (7 to 26) Below range
SHBG: 12.6 nmol/L (18 to 54) Below range
Cortisol was high but within range

I'm thinking that my line of inquiry is whether I am in a good place to have good effects from PM cream or tablets (not sure the cream did much to me to be honest, and maybe this is due to SHBG?), and secondly, what the overall picture might reveal for my health. Even with the doctors and endocrinologist they've never fully told me what they thing is the cause (MRI showed nothing bad with pituitary).

I'd love to have weightloss, and to have full use of my penis. I think this means my DHT and T/totalT need to be much higher.
I'd also love to have super-sensitive nipples that would get erect and help me get orgasms from just my shirt brushing across them.

Do you have links to sites for anti-androgen products?
In order to show my doctor my determination to take anti-androgens whether with a prescription or by myself on the net.

Thanks for your help, or any other member.
Jennifer

Hi Jennifer, I think I addressed your concerns in the x-thread? but let me know if you still need help. 

@Lotus 
I'm so impressed with your biology and endocrine knowledge, I can tell this forum really benefits from all your hard work.

I was wondering if you could pretty please comment on my blood tests from over a year ago? The test was conducted before I played with NBE, and I was suffering from low libido and erectile issues.

Thank you for the kind words, I'd be happy to help, I've got some things to take care of first and then I'll look at the numbers asap.

Thank you for the kind words, I'd be happy to help, I've got some things to take care of first and then I'll look at the numbers asap.

Thank you so much!
I saw on one of your posts about Androstenedione, I have that for the same result-set, it was 3.8 nmol/L where the range was 2.0 to 5.4

I'm taking 500mg PM in the morning and 500mg PM (the puraria.co.uk source via ebay) in the evening, now for 2 days. I dont know if my low SHBG means the PM would have a quicker effect or not.

Also the other things you have written suggests that my low SHBG + obesity points to probable Metabolic Syndrome, so I will try hard to do a low-carb diet to improve my general health; although I'm confused if that would mean that the increase in SHBG would make the PM less effective.

Hi prostatenipple, question for you...and this may rule out what I may suggest if the answer is yes, do take an antidepressant...SSRIs? (selective serotonin reuptake inhibitors), like any of the following below:

Citalopram (Celexa)
Escitalopram (Lexapro)
Fluoxetine (Prozac)
Paroxetine (Paxil, Pexeva)
Sertraline (Zoloft)

Hi prostatenipple, question for you...and this may rule out what I may suggest if the answer is yes, do take an antidepressant...SSRIs? (selective serotonin reuptake inhibitors), like any of the following below:

Citalopram (Celexa)
Escitalopram (Lexapro)
Fluoxetine (Prozac)
Paroxetine (Paxil, Pexeva)
Sertraline (Zoloft)

Nope, never taken any of those listed above.

I've taken other herbs / vitamins in the past. I'm not sure if any of them act as SSRIs or other similar action.

EDIT: I remember in 2018 (possibly when my Testosterone levels started dropping?) I was taking a daily vitamin table Wellman Prostrace, which had some Saw Palmetto. Not sure if SP and Pygeum got me Post-Finasteride Syndrome if it messed with my DHT?

At various times, But not really in the last 6 months, have taken:
- Pygeum (very large doses)
- Lecithin
- L-Arginine / L-Cirtulline
- Garlic extract
- Omega 3 fish oil in large doses (1360mg to 3000mg approx per day)
- vitamin C / Vitamin D3 (5000 - 10000 IU)
- ZMA
- Horny Goat Weed ( a large dose from ebay)
- Maca powder (a heaped teaspoon sometimes)
- Korean Ginseng
- Pycnogenol (Marine Pine bark)
- Beetroot extract
- Fenugreek (14000mg extract)
- Tribulus
- Stinging Nettle Leaf (12000mg)
- Stinging Nettle Root
- Boron (6-12mg daily, discontinued a year ago, may have crashed my SHBG?)
- Damiana (1000mg to 3000mg per day, ad-hoc)
- Ashwaghanda (1000mg or more, dont have dosage details at the moment, I did read this can make people anhedonic, so no pleasure and messes with dopamine? I have discontinued use)
- Vitamin E (100 - 400 IU)
- Zinc (15-50mg per day ad-hoc)
- Celery Seed
- Royal jelly (bee pollen produce)
- L-histidine
- L-Carnitine
- P-5-P (Vitamin B5 to try to lower prolactin)

It's funny, I want my erections and libido to be raring to go hard, but I also want to play with NBE - seems somewhat of a contradiction?

Hi postatenipple,

Apologies for the delayed response, I've given your situation considerable thought, and this is me just taking a moment thinking outside of the box offering an opinion on secondary hypogonadism. Since secondary hypogonadism is characterized by low T due the suppression of hormones, why not treat it with SSRi's (antidepressants) which stimulate breast growth via hypothalamus/pituitary axis. 

That aside, having used SSRI'S myself in the past I'm well aware they stimulate nipple sensitivity and as science proves it induces mammoplasia and galactorrhea (milk discharge). I

Prostatenipple, your estradiol is nonexistent and yourL ĺ SHBG is on life support. I'm not you should take antidepressants, that therapy gives me ideas on which why to go with you. But your a jigsaw on what you want to achieve lol. 

I am confused though, are you taking any testosterone currently? by the looks of your T I'd seen no, because it's not an issue. Your free doesn't look bad either. It's like you have some of the hallmark signs PCOS (polycystic ovarian syndrome) in women have
*insulin insensitivity 
*weight gain
*diabetes?
*low SHBG

I think you should stop the Pygeum, or cut back, that's way too much. I'm still figuring this out, I'm done for tonight though.

Breast enlargement during chronic antidepressant therapy 
https://pubmed.ncbi.nlm.nih.gov/9479619/
In conclusion, antidepressant-induced mammoplasia may be more common than previously expected.

Secondary Hypogonadism in Men
It is clear that obesity lowers the level of sex hormone binding globulin (SHBG), which transports a significant fraction of serum T.
https://www.medpagetoday.com/resource-centers/hypogonadism/secondary-hypogonadism-men/1082

Wow thanks for the awesome reply, Lotus.

I'd like to keep erection quality and libido, so that's the primary goal. I've heard SSRIs can often decrease both, so I'd like to avoid them if possible. The mammoplasia effect is interesting - would it be better to use PM to achieve the same goal?

I've been terrible at explaining the situation, sorry.

The blood test readings I posted are BEFORE I was put on TRT, and BEFORE any NBE activity.

I'm currently on Testogel daily approx 60mg testosterone.

I dont have recent blood tests, only that Total Testosterone was 10.7 a few months ago (during TRT), and estradiol was 96 (rose from 70 before TRT).

The estradiol is mid-range for a male range - did your appraisal of the situation differ now that you know I'm on TRT? Or am I expecting to have higher E2 due to being on TRT? I agree, pre TRT, my SHBG was very low. I dont know what it is today.
My free Test was very low pre-TRT. I dont know what it is now. Doctors dont test for this, unless I get a private test myself that costs a lot.

I've stopped Pygeum completely some 4 months ago.

Your free doesn't look bad either. It's like you have some of the hallmark signs PCOS (polycystic ovarian syndrome) in women have
*insulin insensitivity 
*weight gain
*diabetes?
*low SHBG

Now this is interesting! Can biologically born men (sorry, I dont know the correct term and dont want to cause offense) have PCOS?
I've been pre-diabetes before, I've gained weight (sometimes not really explainable), and I had that low SHBG blood test. Could it be possible?


Thanks so much for your reply