I've been on synthetics for 3 weeks now, and I can vouch for them being stronger than herbs, even on a modest dosage (4 mg estradiol valerate). My boobs hurt more than when I was on PM at 1500 mg/day, and they seem to be growing faster, too.
I'm all in favor of proceeding on the conservative side with the estradiol. I'm talking about a half of what is typically prescribed for a transsexual. I have been ramping up the T-blocker spironolactone, though. I can see going to 200 mg a day if I can tolerate that much. I'm at 100 mg now. So far, so good. My next blood test is in August to check my liver and kidney health. My intention is to return to PM in the fall, or continue with the synthetics under the eye of an endo.
Clara