Hi Bobie,
Not too sure about the effect of prolonged breaks, but one thing you mentioned caught my eye. You said that for a while you were using synthetics (estradiol, spironolactone, finasteride) and I hope you were doing this under the guidance of a medical professional. What caught my eye was the combination of spironolactone and finasteride, not that it's bad but it seems unnecessary. I thought that spironolactone was an antiandrogen prevention the production of testosterone and that finasteride simply prevented testosterone from converting to DHT which, among other things, causes male pattern baldness. So if you prevent the tertosterone production then would there be a need to try to prevent it's conversion since there isn't any to convert?
I hope that some of the more knowledgable members here can shed some light on this.