[Lotus]

Interesting chart in your previous post, Lotus. I have a question for you:

Where is DHT in the chart? Part of the available or unavailable testosterone? Or is it a separate thing altogether?

Clara

Good question, I doubt if one exists lol, it would come from free T, I remember seeing another figure somewhere on a slightly similar percentage.

Approximately 7% of testosterone is reduced to 5α-dihydrotestosterone (DHT) by the cytochrome P450 enzyme 5α-reductase, an enzyme highly expressed in male sex organs and hair follicles. Approximately 0.3% of testosterone is converted into estradiol by aromatase (CYP19A1) an enzyme expressed in the brain, liver, and adipose tissues.

Here's something interesting,

The total estradiol production rate in the human male has been estimated to be 35-45 μg (0.130-0.165 μmol) per day, of which approximately 20% is directly produced by the testes. Roughly 60% of circulating estradiol is derived from direct testicular secretion or from conversion of testicular androgens. The remaining fraction is derived from peripheral conversion of adrenal androgens.

[Lenneth]

Interesting chart in your previous post, Lotus. I have a question for you:

Where is DHT in the chart? Part of the available or unavailable testosterone? Or is it a separate thing altogether?

Clara

Good question, I doubt if one exists lol, it would come from free T, I remember seeing another figure somewhere on a slightly similar percentage.

Approximately 7% of testosterone is reduced to 5α-dihydrotestosterone (DHT) by the cytochrome P450 enzyme 5α-reductase, an enzyme highly expressed in male sex organs and hair follicles. Approximately 0.3% of testosterone is converted into estradiol by aromatase (CYP19A1) an enzyme expressed in the brain, liver, and adipose tissues.

Here's something interesting,

The total estradiol production rate in the human male has been estimated to be 35-45 μg (0.130-0.165 μmol) per day, of which approximately 20% is directly produced by the testes. Roughly 60% of circulating estradiol is derived from direct testicular secretion or from conversion of testicular androgens. The remaining fraction is derived from peripheral conversion of adrenal androgens.

interesting, how does that compare with that of biological females?

[GoneGirl]

Interesting chart in your previous post, Lotus. I have a question for you:

Where is DHT in the chart? Part of the available or unavailable testosterone? Or is it a separate thing altogether?

Clara

Good question, I doubt if one exists lol, it would come from free T, I remember seeing another figure somewhere on a slightly similar percentage.

Approximately 7% of testosterone is reduced to 5α-dihydrotestosterone (DHT) by the cytochrome P450 enzyme 5α-reductase, an enzyme highly expressed in male sex organs and hair follicles. Approximately 0.3% of testosterone is converted into estradiol by aromatase (CYP19A1) an enzyme expressed in the brain, liver, and adipose tissues.

Here's something interesting,

The total estradiol production rate in the human male has been estimated to be 35-45 μg (0.130-0.165 μmol) per day, of which approximately 20% is directly produced by the testes. Roughly 60% of circulating estradiol is derived from direct testicular secretion or from conversion of testicular androgens. The remaining fraction is derived from peripheral conversion of adrenal androgens.

Still wondering, is DHT included in total testosterone or not?

[Lotus]

Still wondering, is DHT included in total testosterone or not?

Good question, I doubt if one exists lol, it would come from free T, I remember seeing another figure somewhere on a slightly similar percentage.

Yes, DHT would come from free T. (As far as a percentage DHT has in the pie chart, slice out 7% of that 2% of free T, lol).

[Lotus]

interesting, how does that compare with that of biological females?

According to the National Institutes of Health, the normal range of testosterone is 30 to 95 nanograms per deciliter (ng/dL) for women and 300 to 1,200 ng/dL for men, but individual laboratories might have a slightly different range that they consider normal. Also keep in mind that the levels vary with age. In women, the level of testosterone in the blood is lowest during puberty and adolescence, and is highest in pre- and post-menopausal women. For men, the levels increase during puberty and stay steady for much of their young adult life. They then slowly begin to decline during middle and older age.
http://www.livestrong.com/article/239396...r-a-woman/


Men and women produce exactly the same hormones, but in different amounts: as a rule, men produce 20 times more testosterone than women, while women produce more estrogen and progesterone. As with most things in nature, this "norm" can become imbalanced, and some women may have higher levels of testosterone, causing a unique set of symptoms.


I probably have enough info on all the useless info on T you can image, lol. A fact sheet should be in order.

[GoneGirl]

Still wondering, is DHT included in total testosterone or not?

Good question, I doubt if one exists lol, it would come from free T, I remember seeing another figure somewhere on a slightly similar percentage.

Yes, DHT would come from free T. (As far as a percentage DHT has in the pie chart, slice out 7% of that 2% of free T, lol).

So if I want to know my DHT level, I would need a separate test for that, right?

Clara

[Lotus]

Still wondering, is DHT included in total testosterone or not?

Good question, I doubt if one exists lol, it would come from free T, I remember seeing another figure somewhere on a slightly similar percentage.

Yes, DHT would come from free T. (As far as a percentage DHT has in the pie chart, slice out 7% of that 2% of free T, lol).

So if I want to know my DHT level, I would need a separate test for that, right?

Clara

It looks like it, I've seen silva and blood tests range from $60 to over $200. The reference ranges will vary as you know with age, bmi and other factors.

Salivary DHT Ranges
(Unsupplemented A.M. Ranges in pg/ml)
Male 10-50 pg/ml Female 6-20 pg/m

Blood DHT test range
adult male 30 - 85 ng/dL


Blood Testing Protocols
http://www.lef.org/protocols/appendix/bl...ing_03.htm

[Lenneth]

interesting, how does that compare with that of biological females?

According to the National Institutes of Health, the normal range of testosterone is 30 to 95 nanograms per deciliter (ng/dL) for women and 300 to 1,200 ng/dL for men, but individual laboratories might have a slightly different range that they consider normal. Also keep in mind that the levels vary with age. In women, the level of testosterone in the blood is lowest during puberty and adolescence, and is highest in pre- and post-menopausal women. For men, the levels increase during puberty and stay steady for much of their young adult life. They then slowly begin to decline during middle and older age.
http://www.livestrong.com/article/239396...r-a-woman/


Men and women produce exactly the same hormones, but in different amounts: as a rule, men produce 20 times more testosterone than women, while women produce more estrogen and progesterone. As with most things in nature, this "norm" can become imbalanced, and some women may have higher levels of testosterone, causing a unique set of symptoms.


I probably have enough info on all the useless info on T you can image, lol. A fact sheet should be in order.

the balance of E - T or T - E Comparison is what I was meaning.

[GoneGirl]

The crazy thing is that as men age and their testosterone level drops, their DHT level increases! This leads to baldness in 70% of men. It also means body hair grows even courser, and the prostate enlarges. Bad stuff that DHT. All men would benefit from taking a drug like Propecia (finasteride) to lower their DHT. WTF good is it?

Clara

[Lotus]

interesting, how does that compare with that of biological females?

According to the National Institutes of Health, the normal range of testosterone is 30 to 95 nanograms per deciliter (ng/dL) for women and 300 to 1,200 ng/dL for men, but individual laboratories might have a slightly different range that they consider normal. Also keep in mind that the levels vary with age. In women, the level of testosterone in the blood is lowest during puberty and adolescence, and is highest in pre- and post-menopausal women. For men, the levels increase during puberty and stay steady for much of their young adult life. They then slowly begin to decline during middle and older age.
http://www.livestrong.com/article/239396...r-a-woman/


Men and women produce exactly the same hormones, but in different amounts: as a rule, men produce 20 times more testosterone than women, while women produce more estrogen and progesterone. As with most things in nature, this "norm" can become imbalanced, and some women may have higher levels of testosterone, causing a unique set of symptoms.


I probably have enough info on all the useless info on T you can image, lol. A fact sheet should be in order.

the balance of E - T or T - E Comparison is what I was meaning.

This is not an easy find, and probably not the comparison you were looking for. The numbers and values are all over the place, however for the most part other factors and considerations have to be considered when testing or getting averages, (e.g. testing times, age, bmi, health, etc.). It's still missing a few things so I'll add to it as I find the info.

Endogenous avg. produced daily (males)

MEN
-Hormone ( FSH): 2 - 18 mIU/ml
-Testosterone 3mg to 10mg (daily)
-Prolactin 7 - 18 ng/ml
-FT-Free T is about 2% (this is the functional T)
-BT-Bound T or 98%
-Albumin 38% (bloodstream)
-SHBG is 60% (sex-hormone-binding-globulin)
-DHT approximately 7% of T is reduced by 5 ar
-Estradiol approximately 0.3% of testosterone is converted into E2 by aromatase (CYP19A1) of that 0.3%, 20% is directly produced by the testes. Roughly 60% of circulating estradiol is derived from direct testicular secretion or from conversion of testicular androgens. The remaining fraction is derived from peripheral conversion of adrenal androgens. The serum levels of estradiol in males (14 - 55 pg/mL) are roughly comparable to those of postmenopausal women (< 35 pg/mL).

Endogenous avg. produced daily (females)

WOMEN
-Testosterone 0.05 mg (produced daily)
-FT-Free T normal calculated free testosterone is 0.4 – 0.8 ng/dl (or 40 – 80 pg/dl).
-Albumin 34% bloodstream)
-SHBG is 66% (sex-hormone-binding-globulin)
-Estradiol 70 to 500 mg of estradiol daily, (depending on the phase of the menstrual cycle. This is converted primarily to estrone, which circulates in roughly equal proportion to estradiol, and to small amounts of estriol.)
-Estradiol in postmenopausal women (< 35 pg/mL).
-Progesterone levels tend to be < 2 ng/ml prior to ovulation, and > 5 ng/ml after ovulation. If pregnancy occurs, human chorionic gonadotropin is released maintaining the corpus leuteum allowing it to maintain levels of progesterone.

Avg tests

Hormone Follicular Day of LH Surge Mid-luteal
-Follicle Stimulating (FSH) < 10 mIU/ml > 15 mIU/ml -
-Luteinizing Hormone-(LH) < 7 mIU/ml > 15 mIU/ml -
-Prolactin < 25 ng/ml
-Thyroid Stimulating Hormone 0.4 - 3.8 uIU/ml (TSH)
-Estradiol ( E2) < 50 pg/ml ( Day 3) > 100 pg/ml
-Progesterone < 1.5 ng/ml > 15 ng/ml




Reference Values
Free Estradiol, Percent
Reference Ranges (%)

Adult Males 1.7 - 5.4
Adult Females 1.6 - 3.6

Free Estradiol, Serum
Reference Ranges (pg/mL)

Adult Males 0.2 - 1.5
Adult Females 0.6 - 7.1

Sex Hormone Binding Globulin (SHBG), Serum
Reference Ranges
Adult Males 20 - 60
Adult Female
Premenopausal 40 - 120
Postmenopausal 28 - 112


the most complete list here:
http://wikipedia.org/wiki/Reference_rang...lood_tests