[Holmes12]

This may well already have been covered, I googled herbs with anti androgenic properties, the usual suspects were listed along with liquorice, which was stated to be more potent than Saw palmetto, although long term use was not advised due to adverse effects of the body's potassium level.

Has anyone here used or have any info on Liqourice, I'm thinking of upping my anti androgenic herbal intake.

[Candace]

I can think of two reasons to avoid licorice. First, as Lotus pointed out earlier, it has the side-effect of inhibiting 11β-hydroxysteroid dehydrogenase type 2. This increases cortisol in some parts of the body which can increase blood pressure. Elevated cortisol is part of how stress kills people, so I still wouldn't feel safe even if my blood pressure was still normal while taking it. (Licorice doesn't affect the type 1 dehydrogenase, so it isn't a substitute for corticosteroid drugs.)

Second, glycyrrhizin blocks gap junction intercellular communication. Gap junction intercellular communication allows healthy cells to stick together and inhibit tumor proliferation. Improving gap junction communication is believed to be one of the ways that vitamin D prevents cancer, particularly breast and colon cancer. 1 2 3

[Candace]

I found the full text of the reishi 5-AR inhibition paper. The doses they used in rats were either 0.3% of diet as unextracted mushrooms or 1.5 mg/kg of the extract.

1.5 mg/kg divide by 6.2 going from rats to humans times 70 kg human = 17 mg extract. A gram of Swanson's best extract has 80 mg of triterpenes (which do the 5-AR inhibition), so it should work.

For unextracted mushrooms, 0.3% of diet = 3000 mg/kg diet. A rat eats 5 g diet per 100 g body which makes it 150 mg/kg. Divide by 6.2 times 70 kg human = 1.7 grams mushrooms.

[Lotus]

Lotus. What is the strongest DHT blocker?Why does it needs Cink,Pumkin seed capsules?

Hi Larana, if it's herbal?, I'd say Reishi is the strongest option, other info is posted below for reference.

Has anyone here used or have any info on Liqourice, I'm thinking of upping my anti androgenic herbal intake.

Hi Holmes, you'll find more info on licorice below, honestly I think Reishi is a better bet, and I recently found that it also has estrogenic activity.

FAQ-What's the NBE role of each anti-androgen
http://www.breastnexus.com/showthread.php?tid=19578

I found the full text of the [url=http://reishi.setamed.com/articulos/art20.pdf]reishi 5-AR inhibition paper[url]. The doses they used in rats were either 0.3% of diet as unextracted mushrooms or 1.5 mg/kg of the extract.

Great finds Candace, thanks. This is what I have on Reishi, and with a current update on the estrogenic activity of Reishi, and now making it a strong contender and (imo) a multi purpose adaptogen.

Ganoderma lucidum is Reishi mushrooms

Estrogen-like activity of ethanol extract of Ganoderma lucidum
http://www.researchgate.net/publication/...ma_lucidum


Ganoderma lucidum inhibits proliferation of human breast cancer cells by down-regulation of estrogen receptor and NF-kappaB signaling.
http://www.ncbi.nlm.nih.gov/pubmed/16865287


Ganoderma lucidum: a potent pharmacological macrofungus
http://www.ncbi.nlm.nih.gov/pubmed/19939212

Ganoderma lucidum contain approximately 400 different bioactive compounds, which mainly include triterpenoids, polysaccharides, nucleotides, sterols, steroids, fatty acids, proteins/peptides and trace elements which has been reported to have a number of pharmacological effects including immunomodulation, anti-atherosclerotic, anti-inflammatory, analgesic, chemo-preventive, antitumor, chemo and radio protective, sleep promoting, antibacterial, antiviral (including anti-HIV), hypolipidemic, anti-fibrotic, hepatoprotective, anti-diabetic, anti-androgenic, anti-angiogenic, anti-herpetic, antioxidative and radical-scavenging, anti-aging, hypoglycemic, estrogenic activity and anti-ulcer properties. Ganoderma lucidum has now become recognized as an alternative adjuvant in the treatment of leukemia, carcinoma, hepatitis and diabetes.

5alpha-reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum.
http://www.ncbi.nlm.nih.gov/pubmed/16462054

Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells
http://boliviapuertapuerta.com/img/DXN/art18.pdf

Anti-cancer activities of Ganoderma lucidum: active ingredients and pathways
http://functionalfoodscenter.net/files/63502376.pdf

[Larana]

Lotus. What is the strongest DHT blocker?Why does it needs Cink,Pumkin seed capsules?

Hi Larana, if it's herbal?, I'd say Reishi is the strongest option, other info is posted below for reference.

Has anyone here used or have any info on Liqourice, I'm thinking of upping my anti androgenic herbal intake.

Hi Holmes, you'll find more info on licorice below, honestly I think Reishi is a better bet, and I recently found that it also has estrogenic activity.

FAQ-What's the NBE role of each anti-androgen
http://www.breastnexus.com/showthread.php?tid=19578

I found the full text of the [url=http://reishi.setamed.com/articulos/art20.pdf]reishi 5-AR inhibition paper[url]. The doses they used in rats were either 0.3% of diet as unextracted mushrooms or 1.5 mg/kg of the extract.

Great finds Candace, thanks. This is what I have on Reishi, and with a current update on the estrogenic activity of Reishi, and now making it a strong contender and (imo) a multi purpose adaptogen.

Ganoderma lucidum is Reishi mushrooms

Estrogen-like activity of ethanol extract of Ganoderma lucidum
http://www.researchgate.net/publication/...ma_lucidum


Ganoderma lucidum inhibits proliferation of human breast cancer cells by down-regulation of estrogen receptor and NF-kappaB signaling.
http://www.ncbi.nlm.nih.gov/pubmed/16865287


Ganoderma lucidum: a potent pharmacological macrofungus
http://www.ncbi.nlm.nih.gov/pubmed/19939212

Ganoderma lucidum contain approximately 400 different bioactive compounds, which mainly include triterpenoids, polysaccharides, nucleotides, sterols, steroids, fatty acids, proteins/peptides and trace elements which has been reported to have a number of pharmacological effects including immunomodulation, anti-atherosclerotic, anti-inflammatory, analgesic, chemo-preventive, antitumor, chemo and radio protective, sleep promoting, antibacterial, antiviral (including anti-HIV), hypolipidemic, anti-fibrotic, hepatoprotective, anti-diabetic, anti-androgenic, anti-angiogenic, anti-herpetic, antioxidative and radical-scavenging, anti-aging, hypoglycemic, estrogenic activity and anti-ulcer properties. Ganoderma lucidum has now become recognized as an alternative adjuvant in the treatment of leukemia, carcinoma, hepatitis and diabetes.

5alpha-reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum.
http://www.ncbi.nlm.nih.gov/pubmed/16462054

Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells
http://boliviapuertapuerta.com/img/DXN/art18.pdf

Anti-cancer activities of Ganoderma lucidum: active ingredients and pathways
http://functionalfoodscenter.net/files/63502376.pdf

I thouhght the reishi is a testosteron blocker,not only DHT,isn't?

[Lotus]

I thouhght the reishi is a testosteron blocker,not only DHT,isn't?

Larana,

From the research, Reishi has many benefits, inhibiting (or blocking) DHT by the enzyme 5 alpha reductase is what we're concerned about, (which it does). Without getting to technical, another of Reishi's many benefits (and recently discovered, although it's been in the research reports for sometime) is its estrogenic properties. I don't think we can find another herbal that can do as much as Reishi for NBE and inhibiting DHT and offer other benefits. Pumpkin seed oil is a close second, PSO reminds me of spironolactone (some of its actions, a topic for another discussion lol).

Pumpkin seed oil
http://www.breastnexus.com/showthread.php?tid=17416&page=28 (Post 275)


Sorry to cause any alarms, the info was to inform BN members on additional benefits.

[Candace]

I thouhght the reishi is a testosteron blocker,not only DHT,isn't?

Correct. It hits both 5-AR and the androgen receptor.

[elainecd]

So whats the best form to purchase reishi in?
and please when should I add it to my PM program?

I see it in capsules at walmart and walgreens.
Reishi Mycelium (Mushroom) Extract 376 mg
recommended 2 a day.
Thank you .

[Lotus]

I thouhght the reishi is a testosteron blocker,not only DHT,isn't?

Correct. It hits both 5-AR and the androgen receptor.

The down-regulation of AR signaling by ganoderol B provides an important mechanism for its anti-androgenic activity. However, Reishi's ability to bind to human estrogen receptors (hERs) α and β of the ethanol extract of G. lucidum was confirmed by using the coactivator-bacterial alkaline phosphatase system, and it's ability to inhibit 5 ar imo takes precedence.

[Candace]

So whats the best form to purchase reishi in?
and please when should I add it to my PM program?

This LEF product has the ReishiMax extract that was used in the impressive studies.

This Swanson product seems close enough and is cheaper than ReishiMax. It's the triterpenes that do the 5-AR inhibition, so that's the metric to compare. The polysaccharides just help the immune system fight cancer.

I take two caps per day of the Swanson extract and it doesn't need to be cycled.