18-11-2014, 07:59 PM
We've only had one thread on half life's, time to unlock NBE (hrt too) and explore the timing of when and how much to take: 
Half-life: The period of time required for the concentration or amount of drug in the body to be reduced to exactly one-half of a given concentration or amount.
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The half-life of steroid hormone receptors ranges from 2 to 4 hours for ERα 4 hours for AR, 7 to 10 hours for PR, and 19 hours for GR. The relatively long half-life of the steroid hormone receptors strongly suggests that the receptor proteins are recycled before eventual degradation.
Single-dose pharmacokinetics of sublingual versus oral administration of micronized 17 beta-estradiol
CONCLUSION:
Sublingual administration of micronized 17 beta-estradiol results in a rapid, burst-like absorption into the systemic circulation, yielding high E2 levels that fall rapidly over the first 6 hours.
http://www.ncbi.nlm.nih.gov/pubmed/9052581
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The apparent half-life of E2 after discontinuing a transdermal E2 patch is 2.7 h or 161 min.
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The kinetics of Puerarin (after 7.5g/kg water extract of the decoction) were a half-life of 46.9 minutes (β-Half life of 925.7min) and AUC of 790.3μ min/mL; a Cmax of 1.41ug/mL (3.39umol/L) and a Tmax of 18.5 minutes; suggesting rapid absorption.
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Elimination half-life of endogenous testosterone is 10 to 100 minutes and is dependent on the amount of free testosterone in the plasma. Exogenous testosterone, such as testosterone cypionate (when injected intra-muscularly) has a half-life of approximately eight days.
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Fenugreek has a "shelf life of 5 years" (any preppers lol?)
Half-life: The period of time required for the concentration or amount of drug in the body to be reduced to exactly one-half of a given concentration or amount.
---------------------------
The half-life of steroid hormone receptors ranges from 2 to 4 hours for ERα 4 hours for AR, 7 to 10 hours for PR, and 19 hours for GR. The relatively long half-life of the steroid hormone receptors strongly suggests that the receptor proteins are recycled before eventual degradation.
(17-11-2014, 03:09 AM)Lotus Wrote: Steroid hormones generally autoregulate their receptor levels. Desensitization or downregulation of receptor numbers, measured by decreased ligand binding capacity, occurs in response to exposure to high levels of ligand and involves the reduction in receptor mRNA levels, decreasing the number of available receptors. The receptor gene may be negatively regulated by the hormonal ligand itself through its receptor protein interacting with specific HREs in the gene. Upregulation or self-priming may occur in an analogous fashion. Steroid hormones can regulate receptor levels for other hormones (e.g. E2 increases PR levels in estrogen-responsive tissues). Progesterone can downregulate its own receptors, as well as ERα and ERβ. This increase or decrease in receptor levels in homologous or heterologous regulation can be caused by alterations in receptor gene transcription or decay rates for receptor mRNA or protein.
(17-11-2014, 03:09 AM)Lotus Wrote: So imo take what we know about NBE and throw out the play book. Meaning a confusion exists (well imo) of when and how long to take supplements that will be effective. It also explains that how receptor recycling (degradation) and not just steriod receptors gets excreted and recycled again and again. What this means is (and I'll try to explain so all can follow), that taking supplements in shorter (and less) bursts to follow the steroid half life's (this means receptor control too) cycle.
Single-dose pharmacokinetics of sublingual versus oral administration of micronized 17 beta-estradiol
CONCLUSION:
Sublingual administration of micronized 17 beta-estradiol results in a rapid, burst-like absorption into the systemic circulation, yielding high E2 levels that fall rapidly over the first 6 hours.
http://www.ncbi.nlm.nih.gov/pubmed/9052581
___________________________
The apparent half-life of E2 after discontinuing a transdermal E2 patch is 2.7 h or 161 min.
___________________________
The kinetics of Puerarin (after 7.5g/kg water extract of the decoction) were a half-life of 46.9 minutes (β-Half life of 925.7min) and AUC of 790.3μ min/mL; a Cmax of 1.41ug/mL (3.39umol/L) and a Tmax of 18.5 minutes; suggesting rapid absorption.
__________________________
Elimination half-life of endogenous testosterone is 10 to 100 minutes and is dependent on the amount of free testosterone in the plasma. Exogenous testosterone, such as testosterone cypionate (when injected intra-muscularly) has a half-life of approximately eight days.
____________________________
Fenugreek has a "shelf life of 5 years" (any preppers lol?)