Here's an interesting study,
Studies in male-to-female transsexuals have shown that both flow-mediated and nitroglycerin-induced vasodilations in the brachial artery are enhanced compared with control men, suggesting that high-dose estrogen treatment enhances vascular reactivity in genetic males.
Low-Dose Estrogen Supplementation Improves Vascular Function in Hypogonadal Men
http://hyper.ahajournals.org/content/38/5/1011.full
There might be a correlation to vasoconstriction and increased levels of estradiol, (more so in genetic males). PM is the closest to E2 by as much as 25%, so when dosages exceed the normal amounts, one has to associate the elevated risk in comparison.
A few other things to consider in vasoconstriction, Calcium supplementation is advised by some of the manufacturers of PM, which when doing so will increase some cardiovascular events. Calcium is poorly absorbed, so it stands to reason as we increase the dosage of PM, calcium increases too right?, well, not so fast.
Quote:Cardiovascular impact
A study investigating the effects of personal calcium supplement use on cardiovascular risk in the Women’s Health Initiative Calcium/Vitamin D Supplementation Study (WHI CaD Study) found a modestly increased risk of cardiovascular events, particularly myocardial infarction in postmenopausal women. A broad recommendation of calcium/vitamin D supplements is therefore not warranted.[48] In contrast, the authors of a 2013 literature review concluded that the benefits of calcium supplementation, such as on bone health, appear to outweigh any risk calcium supplementation may theoretically pose to the cardiovascular health.[49]
http://wikipedia.org/wiki/Calcium
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It does seem possible that all this has an effect on fasciculations, I ran into the same thing with intense ankle and shine (bone) pain while on increased dosages of PM. Misty, we have a lot in common from back surgery to age lol, years ago I started to get what was called myoclonus (myoclonic jerks) or muscle fascicultactions. I attributed this to some of the meds I was on (neurontin) and fibromyalgia, but I think it went further than that.
I also believe it was from caffeine, partially hydrogenated oils (non-dairy creamers), stress, lack of excessive, and an overload of meds/supplements. The way out is (imo) a good ratio of omega 3's and 6's, fruits, veggies, greens etc. Some diets come close, the Mediterranean Diet comes to mind, although I would exclude a few things.
At our age we (genetic males) produce more estrogen than post-menopausal women, E1 to be exact. Yeah, it's a slow-go in terms of wanting fast NBE results or even control of GID, but factor in all the daily xeno's and boom, we're already estro dominate by then. PM needs a metabolic activation to be of any benefit, so even at a low dose it should do its job, and as the study pointed out, we have somewhere between 20- to 80,000 E receptors per cell, not all gets activated. And to talk about receptor sensitivity?, well lol, I won't clog up the thread or those receptors.