31-01-2015, 09:49 PM
Thanks Froger, I needed a good laugh.
I intended to add more of the new info today but we are experiencing some technical issues (its being addressed).
However I will attempt to slip this new pathway in while I can. And it's called "pentose phosphate pathway" or "PPP" (btw my pervy friends that's not a penthouse thing).
PPP occurs exclusively in the cytoplasm, and is found to be most active in the liver, mammary gland and adrenal cortex in the humans.
The primary results of the pathway are:
The generation of reducing equivalents, in the form of NADPH, used in reductive biosynthesis reactions within cells (e.g. fatty acid synthesis).
Production of ribose-5-phosphate (R5P), used in the synthesis of nucleotides and nucleic acids.
Production of erythrose-4-phosphate (E4P), used in the synthesis of aromatic amino acids.
Aromatic amino acids, in turn, are precursors for many biosynthetic pathways
Dietary pentose sugars derived from the digestion of nucleic acids may be metabolized through the pentose phosphate pathway, and the carbon skeletons of dietary carbohydrates may be converted into glycolytic/gluconeogenic intermediates.
_____________________________________
The potential benefit.
The following article is circulated throughout the body building world. Aside from that, you probably won't find anybody drawing the conclusion the a potential advancement of technologies exists here in the nbe world lol, except maybe yours truly.
The point on this is we can say that after PE workouts when the body is in recovery mode estrogen plays a significant role in recovery. Now imo, utilizing this new PPP pathway, adding fatty acids/polyphenols (green tea) afterwards will help the growth phase of breast growth. If you remember reducing inflammation and oxidative stress is an excellent way to also produce favorable breast growth potential.
Glucose Utilization and Estrogen
Estrogen may play an even more vital role in promoting an anabolic state by affecting glucose utilization in muscle tissue. This occurs via an altering the level of available glucose 6-phosphate dehydrogenase. G6PD is an important enzyme in the support anabolism, as it is directly tied to the use of glucose for muscle growth and recuperation[viii] [ix]. During the period of regeneration after skeletal muscle damage, levels of G6PD are shown to rise dramatically. G6PD enzyme plays a vital role in what is known as the pentose phosphate pathway, and as such this rise is believed to enhance the PPP related process in which nucleic acids and lipids are synthesized in cells; fostering the repair of muscle tissue.
A 1980 study at the University of Maryland has shown that levels of glucose 6-phosphate dehydrogenase rise after administration of testosterone propionate, and further that the aromatization of testosterone to estradiol is directly responsible for this increase.[x] In this study neither dihydrotestosterone nor fluoxymesterone could mimic the affect of testosterone propionate on levels of G6PD, an affect that was also blocked by the addition of the potent anti-aromatase 4-hydroxyandrostenedione to testosterone. 17-beta estradiol administration caused a similar increase in G6PD, which was not noticed when its inactive estrogen isomer 17-alpha estradiol (unable to bind the estrogen receptor) was given. An anti-androgen could also not block the positive action of testosterone. This study provides one of the first palatable explanations for a direct and positive effect of estrogen on muscle tissue.
What does this all mean?
It is a long held belief among athletes that estrogen maintenance drugs can slightly hinder muscle gains during steroid therapy with a strong aromatizable steroid such as testosterone. Whether or not we have plausibly explained this remains to be seen, however the above evidence certainly does provide strong support for a direct and positive affect of estrogen on growth. Does this mean we should abandon estrogen maintenance drugs? I don’t think that should be the case. It is important to remember that estrogen can deliver many unwanted effects such as increased water retention, fat deposition and the development of female breast tissue when it becomes too active in the male body. Clearly if we plan a high-dose cycle with an aromatizable steroid, anti-estrogens will be an important inclusion. However we cannot ignore the suggestion of using estrogen maintenance drugs only when they are necessary to combat visible side effects during mild to moderately dosed cycles,especially if bulk is the ultimate goal of the athlete.
--------------------------
Glucose-6-phosphate dehydrogenase (G6PD or G6PDH)
There is an enzyme present in the pentose phosphate pathway , Glucose-6-phosphate dehydrogenase (G6PD or G6PDH) a metabolic pathway (chemical reaction) that supplies reducing energy to cells (such as erythrocytes) by maintaining the level of the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH). The NADPH in turn maintains the level of glutathione in these cells that helps protect the red blood cells against oxidative damage. Of greater quantitative importance is the production of NADPH for tissues actively engaged in biosynthesis of fatty acids and/or isoprenoids, such as the liver, mammary glands, adipose tissue, and the adrenal glands. G6PD reduces nicotinamide adenine dinucleotide phosphate (NADP) to NADPH while oxidizing glucose-6-phosphate.
I intended to add more of the new info today but we are experiencing some technical issues (its being addressed).
However I will attempt to slip this new pathway in while I can. And it's called "pentose phosphate pathway" or "PPP" (btw my pervy friends that's not a penthouse thing).
PPP occurs exclusively in the cytoplasm, and is found to be most active in the liver, mammary gland and adrenal cortex in the humans.
The primary results of the pathway are:
The generation of reducing equivalents, in the form of NADPH, used in reductive biosynthesis reactions within cells (e.g. fatty acid synthesis).
Production of ribose-5-phosphate (R5P), used in the synthesis of nucleotides and nucleic acids.
Production of erythrose-4-phosphate (E4P), used in the synthesis of aromatic amino acids.
Aromatic amino acids, in turn, are precursors for many biosynthetic pathways
Dietary pentose sugars derived from the digestion of nucleic acids may be metabolized through the pentose phosphate pathway, and the carbon skeletons of dietary carbohydrates may be converted into glycolytic/gluconeogenic intermediates.
_____________________________________
The potential benefit.
The following article is circulated throughout the body building world. Aside from that, you probably won't find anybody drawing the conclusion the a potential advancement of technologies exists here in the nbe world lol, except maybe yours truly.
The point on this is we can say that after PE workouts when the body is in recovery mode estrogen plays a significant role in recovery. Now imo, utilizing this new PPP pathway, adding fatty acids/polyphenols (green tea) afterwards will help the growth phase of breast growth. If you remember reducing inflammation and oxidative stress is an excellent way to also produce favorable breast growth potential.
Glucose Utilization and Estrogen
Estrogen may play an even more vital role in promoting an anabolic state by affecting glucose utilization in muscle tissue. This occurs via an altering the level of available glucose 6-phosphate dehydrogenase. G6PD is an important enzyme in the support anabolism, as it is directly tied to the use of glucose for muscle growth and recuperation[viii] [ix]. During the period of regeneration after skeletal muscle damage, levels of G6PD are shown to rise dramatically. G6PD enzyme plays a vital role in what is known as the pentose phosphate pathway, and as such this rise is believed to enhance the PPP related process in which nucleic acids and lipids are synthesized in cells; fostering the repair of muscle tissue.
A 1980 study at the University of Maryland has shown that levels of glucose 6-phosphate dehydrogenase rise after administration of testosterone propionate, and further that the aromatization of testosterone to estradiol is directly responsible for this increase.[x] In this study neither dihydrotestosterone nor fluoxymesterone could mimic the affect of testosterone propionate on levels of G6PD, an affect that was also blocked by the addition of the potent anti-aromatase 4-hydroxyandrostenedione to testosterone. 17-beta estradiol administration caused a similar increase in G6PD, which was not noticed when its inactive estrogen isomer 17-alpha estradiol (unable to bind the estrogen receptor) was given. An anti-androgen could also not block the positive action of testosterone. This study provides one of the first palatable explanations for a direct and positive effect of estrogen on muscle tissue.
What does this all mean?
It is a long held belief among athletes that estrogen maintenance drugs can slightly hinder muscle gains during steroid therapy with a strong aromatizable steroid such as testosterone. Whether or not we have plausibly explained this remains to be seen, however the above evidence certainly does provide strong support for a direct and positive affect of estrogen on growth. Does this mean we should abandon estrogen maintenance drugs? I don’t think that should be the case. It is important to remember that estrogen can deliver many unwanted effects such as increased water retention, fat deposition and the development of female breast tissue when it becomes too active in the male body. Clearly if we plan a high-dose cycle with an aromatizable steroid, anti-estrogens will be an important inclusion. However we cannot ignore the suggestion of using estrogen maintenance drugs only when they are necessary to combat visible side effects during mild to moderately dosed cycles,especially if bulk is the ultimate goal of the athlete.
--------------------------
Glucose-6-phosphate dehydrogenase (G6PD or G6PDH)
There is an enzyme present in the pentose phosphate pathway , Glucose-6-phosphate dehydrogenase (G6PD or G6PDH) a metabolic pathway (chemical reaction) that supplies reducing energy to cells (such as erythrocytes) by maintaining the level of the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH). The NADPH in turn maintains the level of glutathione in these cells that helps protect the red blood cells against oxidative damage. Of greater quantitative importance is the production of NADPH for tissues actively engaged in biosynthesis of fatty acids and/or isoprenoids, such as the liver, mammary glands, adipose tissue, and the adrenal glands. G6PD reduces nicotinamide adenine dinucleotide phosphate (NADP) to NADPH while oxidizing glucose-6-phosphate.
