[Charlie_girl]

Dear awesome and brilliant Lotus, have I offended thee? Lol. I tried to message you back about the maca question you answered for me and it wouldn't let me. I just wanted to say thank you for your help and input. I'm sure your inbox is swamped with questions from people and I appreciate you taking the time to help me out

[Lotus]

Thanks Charlie,

Offended?, nah. I try to keep the pm box cleared (for the most part), but, we've had some technical issues too, so problems do occur. No big thing though, I'm good.

[pom19]

Lotus, I hope you are having a wonderful weekend. <3 POM

[Lotus]

Lotus, I hope you are having a wonderful weekend. <3 POM

Thanks POM, I hope the same for you.

[Lotus]

The illustration shows the positions of HSD's (Hydroxysteroid Dehydrogenases) see how it's involved between positions?, pretty significant huh?. The arrows mean up & down regulation between positions. (That includes the half arrows between the HSD's). Previously HSD's, we're thought to be anti-androgens, but they can be influenced as stated previously, cool, eh.

This is a bit over simplified but Hydroxysteroid Dehydrogenases (HSDs) act like a gate-keeper just before steroids (hormones) bind to receptors (synthesis). Furthermore, these "gate-keepers" can flip the switch (a light switch) on/off to allow passage to the cell receptors. So in essence, they can inhibit or promote hormone activity. Finding a new class of HSD's is the next step, Aldo-keto reductases (AKRs) can help us get there.

   

[Lotus]

Androgens from adrenal pathway (DHEA & DHEAS) go through a back doors of sorts to 4 Dione (androstenedione), which in turn can be synthesized by aromatase to E1.


Btw, did you know that the skin acts as one big hormone receptor!, that's right, beneath the layers of skin sits all the hormone molecules. Estrogens sit inside the fat tissues (aka adipose), the process of first pass metabolism is generally ignored, meaning the liver. And in this case offers one of the biggest opportunities to get at hormones that are in the "free" state (the active hormones).
This illustrates a transdermal application, but you get the idea.



   

[pom19]

My goodness Lotus, you are good at what you do. Thanks again, POM

[Lotus]

My goodness Lotus, you are good at what you do. Thanks again, POM

That's nice of you to say POM, thank you.

[Lotus]

If you can't go without coffee here's a way to add some balance with hormones,

Put 1 tablespoon (or less) of coconut oil into 1 cup of coffee, mix them together in a blender, nutri-ninja, nutra-bullet etc, and wham-o instant latte.

I'm going to try it like that with green tea and coconut oil.

[pom19]

How about this Lotus:

http://www.realfarmacy.com/everyone-sudd...er-coffee/