[Lotus]

Wow I forgot about this, but it's another potential tool for fighting DHT. (Fat men rejoice lol)


Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells.
In prostate cells AKR1C2 acts as a 3-ketosteroid reductase to eliminate 5alpha-DHT and prevents activation of the androgen receptor. AKR1C2 does not act as an oxidase due to either potent product inhibition by NADPH or because it cannot surmount the oxidative 17beta-HSD present. Neither AKR1C2, retinol dehydrogenase/3alpha-HSD nor 11-cis-retinol dehydrogenase is a source of 5alpha-DHT in PC-3 cells.
http://www.ncbi.nlm.nih.gov/pubmed/12810547

Androgen inactivation and steroid-converting enzyme expression in abdominal adipose tissue in men.
In conclusion, androgen inactivation was detected in abdominal adipose tissue in men, with higher 3alpha/beta-HSD activity in the s.c. versus Om depot. Higher Om 5alpha-DHT inactivation rates were found in obese compared with lean men. Further studies are required to elucidate whether local androgen inactivation in abdominal adipose tissue is involved in the modulation of adipocyte metabolism and regional fat distribution in men.
http://www.ncbi.nlm.nih.gov/pubmed/17170221

Androgen metabolism in adipose tissue: recent advances.
We speculate that glucocorticoid-induced androgen inactivation could locally decrease the exposure of adipose cells to active androgens and partially remove their inhibitory effect on adipogenesis. We hypothesize that body fat distribution patterns likely emerge from the local adipose tissue balance between active androgens and glucocorticoids in each fat compartment.
http://www.ncbi.nlm.nih.gov/pubmed/19022338

[pom19]

Alright Lotus, you need to translate this- POM

[spanky (aka Lola)]

I might be missing the point, and surely I am oversimplifying, but I think it means that a little (or a lot of) fat will mediate the effect of androgens (in other words, act as an anti-androgen). But then again, my name is spanky.

[Lotus]

Alright Lotus, you need to translate this- POM

Ok, but it may not make much sense,

It's like deconstructing a model (call it a airplane model) that someone else built, only you're working in reverse to deconstruct right. Same applies here, you see a study that states 5 alpha reductase is reduced in the liver, now maybe this study was for cancer research or something similar. Let's take one of these studies,

Role of human type 3 3alpha-hydroxysteroid dehydrogenase (AKR1C2) in androgen metabolism of prostate cancer cells.

Aldo-keto reductases (AKRs) is another superfamily class of enzymes like the Cytochrome P450 enzyme super family, which are present in most tissues of the body, and play important roles in hormone synthesis and breakdown (including estrogen and testosterone synthesis and metabolism), cholesterol synthesis, and vitamin D metabolism. Cytochrome P450 enzymes also function to metabolize potentially toxic compounds, including drugs and products of endogenous metabolism such as bilirubin, principally in the liver.

AKRs are involved in the development and progression of many cancers, as well as chemotherapeutic drug resistance. AKR1B1 and AKR1B10 are overexpressed in tumors, such as liver, breast, and lung cancer. Several AKRs (AKR1A1, AKR1B10, and AKR1C1-3) are involved in tobacco-carcinogenesis, but they also catalyze the detoxication of nicotine derived nitrosamino ketones. In addition, AKR1C1-3 enzymes play a key role in the regulation of proliferative signaling in hormone dependent cancers.

So what they did in this study was to cut off the androgen synthesis to the receptors using another steroid , Four human aldo-keto reductases (AKRs) that belong to the AKR1C subfamily function in vitro as 3-keto-, 17-keto- and 20-ketosteroid reductases or as 3alpha-, 17beta- and 20alpha- hydroxysteroid oxidases to varying degrees. By acting as ketosteroid reductases or hydroxysteroid oxidases these AKRs can either convert potent sex hormones (androgens, estrogens and progestins) into their inactive metabolites or they can form potent hormones by catalyzing the reverse reaction. In this manner they may regulate occupancy and trans-activation of steroid hormone receptors.

In English, I want to find the link to activate AKR1c in the liver to shut off the androgen receptors therefore DHT never gets activated, simple right?.

[pom19]

I might be missing the point, and surely I am oversimplifying, but I think it means that a little (or a lot of) fat will mediate the effect of androgens (in other words, act as an anti-androgen). But then again, my name is spanky.

--------------------------------------------------------------
That's what I thought. But, any fat male person That I know is also bald.

[pom19]

Thanks Lotus. You are the best hormone scientist we have here. <3 POM

[Lotus]

I might be missing the point, and surely I am oversimplifying, but I think it means that a little (or a lot of) fat will mediate the effect of androgens (in other words, act as an anti-androgen). But then again, my name is spanky.

--------------------------------------------------------------
That's what I thought. But, any fat male person That I know is also bald.

Spanky that's pretty darn near close, and thanks POM, Mad yes, scientist no lol. Although this stuff is so far out there atm, and honestly I think this could help in treating or answer why another pathway could exist for treating gynecomastia. Not in a sense of androgen reduction, but what/how abdominal fat (subcutaneous fat too) can induce gyno in hypogonadal men.

[pom19]

I might be missing the point, and surely I am oversimplifying, but I think it means that a little (or a lot of) fat will mediate the effect of androgens (in other words, act as an anti-androgen). But then again, my name is spanky.

--------------------------------------------------------------
That's what I thought. But, any fat male person That I know is also bald.

Sparky that's pretty darn near close, and thanks POM, Mad yes, scientist no lol. Although this stuff is so far out there atm, and honestly I think this could help in treating or answer why another pathway could exist for treating gynecomastia. Not in a sense of androgen reduction, but what/how abdominal fat (subcutaneous fat too) can induce gyno in hypogonadal men.

----------------------------------------------------------------

[myboobs]

Let me throw a spanner in this discussion . At present there are studies and experiments going on where by parts of genes are sliced out / replaced . Now if this became succesful than all hormon intake becomes redundant as you can have characteristics of female gene replaced from male gene . Than let nature do its job !!

[The First Aria]

Sounds like another form of Frankenstein, or maybe Dr. Jekyl, Mr. Hyde?