[Lotus]

[quote='rocketmelon' pid='124505' dateline='1405449588']
wild yαm contαins these ...........
16α-hydroxyestrone blocker
β-sitosterol ?
whαt αre they

oh pm hαs αrmo-enzyme thingy too...αnd licorice

so is it T or free T that is a good thing? what do you think of velvet bean...ever heard of it ...think it increases T instead of DHT

sorry if I get any of it wrong seriously some of this goes right over meh brain

and on your bio you take nettle ! for T should I try that for healthy leevls ?

thanx lotus
oh yeh on a random topic (= what made you pick the name the name lotus just wondered if it be some kind of campfire story =B lol
[/quote]

* 16-hydroxyestrone (16alpha-OHE) is a toxic estrogen metabolite that acts as a catalyst for cancer cells increasing the likelihood of both breast and prostate cancer forming and developing into something life threatening.

* β-Sitosterol is one of several phytosterols (plant sterols) with chemical structures similar to that of cholesterol.

* Free T is the bio-active kind of testosterone, making it also the kind that can be converted to DHT, and also converted to E2 through aromatase.

* I would stay away from nettle root, it lowers prolactin and raises T, however it also raise E, crazy!!.

* As far as velvet bean,
WORD OF CAUTION - It should not be used by pregnant or lactating women because it can lower prolactin and it increases testosterone.
http://www.herbalhealer.com/velvetbean.html

[quote='rocketmelon' pid='124505' dateline='1405449588']
oh yeh on a random topic (= what made you pick the name the name lotus just wondered if it be some kind of campfire story =B lol[quote][/quote]

Lol, it was from a rebirth thing so to speak, the lotus retracts into the water at the night and emerges fresh in the sun the next day, also the blue lotus flower is associated with a victory of the spirit over that of wisdom, intelligence and knowledge. I know blah blah, lol.

[rocketmelon]

* 16-hydroxyestrone oh dear it sounds mean

=s better be careful with wild ya

* β-Sitosterol is one of several phytosterols (plant sterols) with chemical structures similar to that of cholesterol.



*!"I would stay away from nettle root, it lowers prolactin and raises T, however it also raise E, crazy!!. ...!.....oh so it raises E and T? but with amo it might be okei


Lol, it was from a rebirth thing so to speak, the lotus retracts into the water at the night and emerges fresh in the sun the next day, also the blue lotus flower is associated with a victory of the spirit over that of wisdom, intelligence and knowledge. I know blah blah, lol.
[/quote]


ohhohohoho ;D you seem too coy oh WISE one ......meh name is just ......I want melons fast so I'm gonna rocket them from mangoes to melons xD

okie think I'm getting it through
OKIE FREE T good in small amounts along as it is with the enzyme amo is GOOD right?
Do women have less free T than men ? or would women more likely to need to increase free T than men .....but increasing T is good to for health and hormonal balance ..is only dHt that needs to be blocked if nbe'ing ...........
.so FREE T = GOOD normal T levels = GOOD monitored DHT levels = GOOD
good?

the bean lowers prolactin so confused http://www.redalyc.org/articulo.oa?id=93911288007

"Mucuna pruriens may help to Boost Testosterone and Human Growth Hormone ... supports muscle function, increases milk production in lactating women,"
I thought it was the perfect bean for me ='( -sniff sniff -
you sure it lowers prolactin did they get it right?

[rocketmelon]

so high LH levels and high estrogen allow normal T levels with out growing a mustache ?.....well I'll better sell meh new Mexican hat then won't need it now eh? haha jk (=

It does seem like LH raises testosterone without raising negative feedback. The correlation between high levels of LH and high estrogen may mean the body aromatases a lot of it on its own. Perhaps by taking more aromatase herbs, more of this is converted into estrogen, than DHT. so DHT must be needed, but excessive body hair may mean there is more than enough DHT. That picture really simplifies a lot of what this thread is about testosterone conversion to DHT or estrogen.
[/quote]

[Dynseli]

wild yαm contαins these ...........
16α-hydroxyestrone blocker
β-sitosterol ?

according to that above it blocks 16α-hydroxyestrone.
Reducing reductase is also important to lower DHT.

[rocketmelon]

the bean also helps with dopa or some sort of neron thing
lol
could that be why theres convfusion over prolactin? the chemistry lowers prolactin but the dopa in the bean when consumed helps it......

I deserve a gold star for my first pass grade in boob-ology xD jk
I've been looking through yours and lovely11 threads I'm very right brained
you know ! I'm an artist and a poet meh math and science is petty and pathetic xD .......you should both add in a dumbed down version haha (;

[Lotus]

* 16-hydroxyestrone oh dear it sounds mean

=s better be careful with wild ya

* β-Sitosterol is one of several phytosterols (plant sterols) with chemical structures similar to that of cholesterol.



*!"I would stay away from nettle root, it lowers prolactin and raises T, however it also raise E, crazy!!. ...!.....oh so it raises E and T? but with amo it might be okei


Lol, it was from a rebirth thing so to speak, the lotus retracts into the water at the night and emerges fresh in the sun the next day, also the blue lotus flower is associated with a victory of the spirit over that of wisdom, intelligence and knowledge. I know blah blah, lol.

ohhohohoho ;D you seem too coy oh WISE one ......meh name is just ......I want melons fast so I'm gonna rocket them from mangoes to melons xD

okie think I'm getting it through
OKIE FREE T good in small amounts along as it is with the enzyme amo is GOOD right?
Do women have less free T than men ? or would women more likely to need to increase free T than men .....but increasing T is good to for health and hormonal balance ..is only dHt that needs to be blocked if nbe'ing ...........
.so FREE T = GOOD normal T levels = GOOD monitored DHT levels = GOOD
good?

the bean lowers prolactin so confused http://www.redalyc.org/articulo.oa?id=93911288007

"Mucuna pruriens may help to Boost Testosterone and Human Growth Hormone ... supports muscle function, increases milk production in lactating women,"
I thought it was the perfect bean for me ='( -sniff sniff -
you sure it lowers prolactin did they get it right?


[/quote]

OKIE FREE T good in small amounts along as it is with the enzyme amo is GOOD right?

yes, it's ok.

Do women have less free T than men ? or would women more likely to need to increase free T than men ...

Yes, women produce about 20x less T then men, just like men have E in their body fat, women have T in theirs. Those crazy body and facial hairs seen are a result of DHT, at least that's what your body is telling you. For guys the tell tale signs of DHT comes in a few ways, facial hair, aggression, along with a few others.

you sure it lowers prolactin did they get it right?

See Page 4 of 6, it states no difference to the yield was seen:

   

[spanky (aka Lola)]

You may have seen this, but thought I'd post it anyway:

Conclusions: High levels of circulating testosterone and low levels of SHBG—both within normal endogenous ranges—are associated with increased risks of prostate cancer. Low levels of circulating estradiol may represent an additional risk factor. Circulating levels of DHT and AAG do not appear to be strongly related to prostate cancer risk. [J Natl Cancer Inst 1996;88:1118–26]

http://jnci.oxfordjournals.org/content/88/16/1118.short

I thought I had seen the opposite conclusion somewhere, that high levels of estradiol were associated with prostate cancer, but this indicates the opposite to be true.

[spanky (aka Lola)]

There is also this, identifying prostate cancer risk factors related to high "bioavailable" SHBG (and low T):

http://www.ncbi.nlm.nih.gov/pubmed/23181478

I would like to understand better the relationship between elevated levels of SHBG and estradiol and prostate cancer risks.

[Lotus]

You may have seen this, but thought I'd post it anyway:

Conclusions: High levels of circulating testosterone and low levels of SHBG—both within normal endogenous ranges—are associated with increased risks of prostate cancer. Low levels of circulating estradiol may represent an additional risk factor. Circulating levels of DHT and AAG do not appear to be strongly related to prostate cancer risk. [J Natl Cancer Inst 1996;88:1118–26]

http://jnci.oxfordjournals.org/content/88/16/1118.short

I thought I had seen the opposite conclusion somewhere, that high levels of estradiol were associated with prostate cancer, but this indicates the opposite to be true.

Hi spanky,

I'll do the best I can explaining what I've found and have come to understand myself, it will be broken up over 2-3 posts. (Sorry)

Does a man's estrogen level impact his risk of prostate cancer?

A high level of one type of estrogen in a man's body might increase his risk of developing prostate cancer. That is one surprising conclusion from a new study which also offers another novel finding -- that high levels of the estrogen considered fuel for breast cancer might offer a protective benefit against prostate cancer.


Details of the research were recently presented at the AACR 101st Annual Meeting 2010.
The health of the prostate has long been considered dependent on the level of the male hormones collectively known as androgens however, it is now recognized that estrogens and their metabolites (estrogen broken down by chemical processes in the body) play a role in its normal growth as well as in prostate cancer.

"The aim of our study was to evaluate the use of estrogen metabolites, as a marker for prostate cancer risk," says Ourania Kosti, PhD, at Georgetown Lombardi Comprehensive Cancer Center.


For the study, the researchers measured estrogens and their metabolites in the urine collected from 77 men with prostate cancer, 77 healthy controls and 37 men that underwent biopsy and but were diagnosed cancer-free.

The relative amounts of the 15 estrogens and estrogen metabolites in the urine of prostate cancer cases were similar to that of non-cancer patients with the exception of the estrogen metabolite 4-OHE1.

"This particular estrogen metabolite appeared to be more abundant among men diagnosed with prostate cancer," explains Kosti.
Kosti says her team also observed that the estrogen metabolites considered as 'harmful' estrogens in breast cancer (16-KE2 and 17-epiE3) are secreted in higher amounts among those without prostate cancer and in lower amounts in those with prostate cancer.

"This suggests that these particular estrogens may have a protective role against prostate cancer development," explains Kosti. "It is possible that different tissues respond to estrogens different ways, therefore the potential role of 16-KE2 and 17-epiE3 in prostate cancer prevention and management should be further explored."

http://www.sciencedaily.com/releases/201...150813.htm


What The Published Literature Says About Testosterone and Prostate Cancer
Excerpts from 23 studies indicating that testosterone does not cause prostate cancer
http://www.encognitive.com/node/12962

[Lotus]

There is also this, identifying prostate cancer risk factors related to high "bioavailable" SHBG (and low T):

http://www.ncbi.nlm.nih.gov/pubmed/23181478

I would like to understand better the relationship between elevated levels of SHBG and estradiol and prostate cancer risks.

Understanding how and why they test for SHBG:

The test for sex hormone binding globulin (SHBG) is primarily ordered in conjunction with other tests to evaluate the status of a person's androgen levels - the male hormones. With men, the issue of concern is testosterone deficiency, while with women the concern is excess testosterone production. A total testosterone may be ordered prior to or along with a SHBG test.

SHBG and testosterone levels may be ordered on an adult male to help determine the cause of infertility, a decreased sex drive, and erectile dysfunction, especially when total testosterone results are inconsistent with clinical signs.

In women, small amounts of testosterone are produced by the ovaries and adrenal glands. Even slight increases in testosterone production can disrupt the balance of hormones and cause symptoms such as lack of menstruation (amenorrhea), infertility, acne, and male pattern hair growth (hirsutism). These symptoms and others are often seen with polycystic ovarian syndrome, a condition characterized by an excess production of androgens. SHBG and testosterone testing may be useful in helping to detect and evaluate excess testosterone production and/or decreased SHBG concentrations.

Testing for free testosterone, albumin level, and one or more other sex hormones, such as prolactin, estradiol, and LH (lutenizing hormone), may also be performed to evaluate a person's existing balance of hormones.

Sometimes, a total testosterone and SHBG are ordered to evaluate free androgens by calculating the Free Androgen Index (FAI). This equation gives doctors an idea of the quantity of testosterone that is not bound (bioavailable testosterone) to SHBG and is calculated as follows: FAI = Total Testosterone / SHBG. In males, a fall in testosterone causes a rise in SHBG, so an FAI or another measure (bioavailable testosterone) is often ordered to detect low levels of free testosterone, which may cause decreased sex drive, loss of muscle mass, decreased bone mass, or occasionally problems with having erections (erectile dysfunction). An elevated FAI may be useful in the evaluation of androgenic alopecia (balding), hirsutism, and severe acne where testosterone levels may be normal.


When is it ordered?
Currently, the SHBG test is not performed frequently or routinely. In many cases, doctors feel that the total testosterone, and perhaps free testosterone, provides sufficient information. SHBG is ordered primarily when the total testosterone results do not seem to be consistent with clinical signs, such as decreased sex drive in men or hirsutism in women.

What does the test result mean?


When the SHBG level is increased beyond what is expected, there is likely to be less free testosterone available to the tissues than is indicated by the total testosterone. If the SHBG concentration is decreased, more of the total testosterone is "bioavailable" - not bound to SHBG. This information may be important in the overall evaluation of an individual with signs and symptoms of a condition related to excess or deficient sex hormone production.

Increased levels may be seen in:

Liver disease
Hyperthyroidism
Eating disorders (anorexia)
Estrogen use (hormone replacement therapy and oral contraceptives)
Decreased sex hormone production (hypogonadism)
Decreases in SHBG are seen with:

Obesity
Polycystic ovarian syndrome
Hypothyroidism
Hirsutism
Androgen (steroid) use
Acne
Cushing disease

Is there anything else I should know?
SHBG concentrations are normally high in children of both sexes. After puberty, SHBG levels decrease more rapidly in males than in females. Levels are normally stable in adults and then begin to increase in the elderly male at the same time that total testosterone levels begin to decrease. In postmenopausal women, SHBG, testosterone, and estrogen concentrations decrease as hormone production by the ovaries tapers off.

Testing for bioavailable testosterone is becoming an increasingly important concept to both doctors and researchers. It may be measured by removing the SHBG-bound testosterone from the collected blood sample and then analyzing what’s left. An estimate can also be calculated using the Free Androgen Index (see above).
http://labtestsonline.org/understanding/.../shbg/tab/