[undecided]

Sounds like another form of Frankenstein, or maybe Dr. Jekyl, Mr. Hyde?

Maybe Dr. Jekyle and Mrs Hyde !! Although, I suspect that any advances in that area are going to be too late for most of us.

[Lotus]

Yes myboobs I know what you're referring to, it's called gene-therapy,

"Introduce a healthy gene in a patient and its product should alleviate the defect caused by a faulty gene or slow the progression of disease"

In a similar way when a hormone binds to a receptor a DNA response is expressed when it binds to the nucleus of the cell and causes an expression or sequence (growth). So in a way we can say it's already being done in NBE lol.

When they can grow an ear on a lab animals back you can imagine what's next lol.

Gene Therapy That Works
http://www.sciencemag.org/content/341/6148/853

[Lotus]

So here's what looks like a one of kind study on SAW PALMETTO, you'll notice some gaping differences which is alarming, they compared about 20 differ at brands of SP.

Fatty Acid and Phytosterol Content of Commercial Saw Palmetto Supplements

http://www.ncbi.nlm.nih.gov/pmc/articles...-03617.pdf





   

[Lotus]

This is a repost, pardon the dust lol. (Really important ones though).

_________________________________________________

As you can see the pathway for Testosterone, Approximately 7% of testosterone is reduced to 5α-dihydrotestosterone (DHT) by the cytochrome P450 enzyme 5α-reductase, an enzyme highly expressed in male sex organs and hair follicles. Approximately 0.3% of testosterone is converted into estradiol by aromatase (CYP19A1) an enzyme expressed in the brain, liver, and adipose tissues. Note-the percentages are slightly off, (multiple sources).

By inhibiting the enzyme 5-alpha reductase and promoting the enzyme aromatase along with your choice phytoestrogens or pharma E is key for breast growth in bio-males.

Herbs that convert aromatase-White Peony, Liorice root, Genistein (PM), BO.

Herbs that help block 5 ar, Licorice root, WP, Reishi, SP, pygeum, nettle root (NR is tricky though), BO (not an herb), chinese skullcap, linolenic acid, green tea, progesterone cream is a strong 5 ar, pumpkin seed oil, linolenic acid.

(Pharma-Dutasteride and Finasteride). Both finasteride and dutasteride undergo extensive hepatic metabolism primarily via the cytochrome P450 3A4 (CYP 3A4) isoenzyme system.

Bruno deLignieres, an impeccable French researcher and Thiery Hertoghe, MD, fourth generation in the most distinguished family of endocrinologists in Belgium, have put forth the notion that rising estrogen levels are more likely to be the initiator of the process and that testosterone and DHT may then be a secondary player (promoter). In fact, phytotherapy (large doses of phytoestrogens - soy) is commonly used in European medical practices to treat BPH.

(Jonathan Wright and Eugene Shippen have written excellent, and popular books, discussing these more far-sighted notions all too commonly overlooked and even rejected in current conventional American Medical thinking.)

Testosterone is reduced by the enzyme 5-a-reductase to DHT which is then thought to be the real culprit. The argument between the use of Saw Palmetto, Pygeum and Pumpkin seeds vs Proscar are both directed at blocking this enzyme. Strangely, DHT is most important for sexual vigor, so blocking this step may have some unintended consequences!

On the other hand, Testosterone is also converted into estradiol by aromatase (producing the aromatic ring). This occurs increasingly with age in the liver but most importantly ... in the fat stores.

http://www.antiaging.com/andropause/andropause2.html

Its been stated here before that the Androgen to Estrogen pathway is easier than the Testosterone to Estrogen pathway, and once again aromatase continues to demonstrate the factual evidence.

A couple of French researchers recently reported this:

Testosterone is reduced by the enzyme 5-a-reductase to DHT which is then thought to be the real culprit. The argument between the use of Saw Palmetto, Pygeum and Pumpkin seeds vs Proscar are both directed at blocking this enzyme. Strangely, DHT is most important for sexual vigor, so blocking this step may have some unintended consequences!

On the other hand, Testosterone is also converted into estradiol by aromatase (producing the aromatic ring). This occurs increasingly with age in the liver but most importantly ... in the fat stores.
Now you see the connection. As we age, and frequently gain increasing fat stores, we are feeding the aromatase connection, increasing our estradiol levels and if this theory holds, increasing the promotion of prostate disease.

Also that rising estrogen levels are more likely to be the initiator of the process and that testosterone and DHT may then be a secondary player (promoter). In fact, phytotherapy (large doses of phytoestrogens - soy) is commonly used in European medical practices to treat BPH.

Another example of the androgen/estrogen pathway:



http://www.antiaging.com/andropause/andropause2.html


Thanks Larana, Janet, Candace (Hi, and a belated welcome), TMS aka Tanya Marie Squirrel (which btw TMS you make laugh) for all your comments.

[pom19]

Lotus wrote:
By inhibiting the enzyme 5-alpha reductase and promoting the enzyme aromatase along with your choice phytoestrogens or pharma E is key for breast growth in bio-males.

(25-04-2014 08:50 PM)Lotus Wrote:
Herbs that convert aromatase-White Peony, Liorice root, Genistein (PM), BO.

Herbs that help block 5 ar, Licorice root, WP, Reishi, SP, pygeum, nettle root (NR is tricky though), BO (not an herb), chinese skullcap, linolenic acid, green tea, progesterone cream is a strong 5 ar, pumpkin seed oil, linolenic acid.
--------------------------------------------------------------
Lotus, by saying convert aromatase, do you mean promoting aromatase? Thanks, POM

[The First Aria]

Would be nice, if you could just step into a machine, like a scanner, and BLAM..... Your a woman.

[myboobs]

Sounds like another form of Frankenstein, or maybe Dr. Jekyl, Mr. Hyde?

Maybe Dr. Jekyle and Mrs Hyde !! Although, I suspect that any advances in that area are going to be too late for most of us.

Maybe not !! They are already doing that at egg fertilisation stage , I also believe they have done that in grown adults for sistic fibrosis . So you never know . Sience is marching at super speed

[spanky (aka Lola)]

Have you any advice on using a paraben-free estrogen cream?

I apologize if this question is addressed elsewhere -- I just couldn't find it.

[Lotus]

Lotus wrote:
By inhibiting the enzyme 5-alpha reductase and promoting the enzyme aromatase along with your choice phytoestrogens or pharma E is key for breast growth in bio-males.

(25-04-2014 08:50 PM)Lotus Wrote:
Herbs that convert aromatase-White Peony, Liorice root, Genistein (PM), BO.

Herbs that help block 5 ar, Licorice root, WP, Reishi, SP, pygeum, nettle root (NR is tricky though), BO (not an herb), chinese skullcap, linolenic acid, green tea, progesterone cream is a strong 5 ar, pumpkin seed oil, linolenic acid.
--------------------------------------------------------------
Lotus, by saying convert aromatase, do you mean promoting aromatase? Thanks, POM

Hi POM, conversion is the synthesis of free testosterone to estrogen, E2 estradiol through the testosterone pathway as shown in the diagrams, so yes it promotes. DHEA can also convert through the androstenedione pathway to E1 estrone, another estrogen (weaker than E1, as seen in post menopause).

[pom19]

Lotus wrote:
By inhibiting the enzyme 5-alpha reductase and promoting the enzyme aromatase along with your choice phytoestrogens or pharma E is key for breast growth in bio-males.

(25-04-2014 08:50 PM)Lotus Wrote:
Herbs that convert aromatase-White Peony, Liorice root, Genistein (PM), BO.

Herbs that help block 5 ar, Licorice root, WP, Reishi, SP, pygeum, nettle root (NR is tricky though), BO (not an herb), chinese skullcap, linolenic acid, green tea, progesterone cream is a strong 5 ar, pumpkin seed oil, linolenic acid.
--------------------------------------------------------------
Lotus, by saying convert aromatase, do you mean promoting aromatase? Thanks, POM

Hi POM, conversion is the synthesis of free testosterone to estrogen, E2 estradiol through the testosterone pathway as shown in the diagrams, so yes it promotes. DHEA can also convert through the androstenedione pathway to E1 estrone, another estrogen (weaker than E1, as seen in post menopause).

--------------------------------------------------------
Thanks Lotus, and PM also promotes aromatase?