[Lotus]

It was only a matter of time when this info would be found, enjoy.

Inhibition of steroid 5a-reductase by specific aliphatic unsaturated/fattyacid
http://www.ncbi.nlm.nih.gov/pmc/articles...1-0210.pdf

fatty acids could function as endogenous inhibitors of 5a-reductase


The most potent was y-Linolenic acid, GLA-aka EPO-Evening Primrose Oil.

[Lotus]

This post is also shared in the anti-androgen thread.

Inhibition of steroid 5a-reductase by specific aliphatic unsaturated/fattyacid
http://www.ncbi.nlm.nih.gov/pmc/articles...1-0210.pdf[/align]

fatty acids could function as endogenous inhibitors of 5a-reductase


The most potent was y-Linolenic acid, GLA-aka EPO-Evening Primrose Oil.

[twinklepose]

I've had no luck finding white peony as a supplement. I can only seem to find teas, and I don't want to mess with teas.

You might also want to look into DIM. http://www.jbc.org/content/278/23/21136.full

Hi Monica,

I ordered off amazon, Iowa Select Herbs White Peony Extract

I hope this helps.

Thanks for this link. What do you all consider the best reishi to use?

Also, what doses for each? I'm on 2,000mg of PM per day. Budding the past few weeks, though nothing visible yet.

[peggy]

The most potent was y-Linolenic acid, GLA-aka EPO-Evening Primrose Oil.

Maybe thats the reason why I did grow last year when I took EPO. I definitely will up my dose to two capsules now. Thanks Lotus.

[Lotus]

The most potent was y-Linolenic acid, GLA-aka EPO-Evening Primrose Oil.

Maybe thats the reason why I did grow last year when I took EPO. I definitely will up my dose to two capsules now. Thanks Lotus.

Peggy, I like the fact that EPO prevents DHT, it also helps to control body fat, a few other healthy things too.

[ellacraig]

The most potent was y-Linolenic acid, GLA-aka EPO-Evening Primrose Oil.

Maybe thats the reason why I did grow last year when I took EPO. I definitely will up my dose to two capsules now. Thanks Lotus.

I'm taking two too! Only for a couple weeks though

[Lotus]

Remember these "on and off" switches?, part of this good news, the other part.....not so good.

----------------------

The good news....…


the reductase responsible for the conversion of estrone (a weak estrogen) to 17b-estradiol (a potent estrogen) is the estrogenic type 1 17b-HSD and is the `on' switch for the estrogen receptor (ER). The oxidase activities responsible for the reverse reaction and the inactivation of 17b-estradiol are the type 2 and type 4 17b-HSDs, and these function as the `off' switch for the ER.

Thus, the activity of these 17b-HSD isoforms may regulate the ligand occupancy of ERa and ERb and their trans- activation in estrogen target tissues (Wu et al., 1993; Andersson, 1995; Labrie et al., 1997; 2000).

Hydroxysteroid dehydrogenases and pre-receptor regulation of steroid hormone action http://humupd.oxfordjournals.org/content...3.full.pdf


---------------------------------

The not so good news.....

Phytoestrogens inhibit human 17b-hydroxysteroid dehydrogenase type 5
http://www.brc.dcs.gla.ac.uk/~rb106x/pub...bition.pdf

This is a bit over simplified but Hydroxysteroid Dehydrogenases (HSDs) act like a gate-keeper just before steroids (hormones) bind to receptors (synthesis). Furthermore, these "gate-keepers" can flip the switch (a light switch) on/off to allow passage to the cell receptors. So in essence, they can inhibit or promote hormone activity. Finding a new class of HSD's is the next step, Aldo-keto reductases (AKRs) can help us get there.

[Lotus]

From the first study,

Type 1, 2 , 4 , 5 (17beta HSD) are breast growth potentiators

5 can go either way.



   

[Naomiko]

I've had no luck finding white peony as a supplement. I can only seem to find teas, and I don't want to mess with teas.

You might also want to look into DIM. http://www.jbc.org/content/278/23/21136.full

Hi Monica,

I ordered off amazon, Iowa Select Herbs White Peony Extract

I hope this helps.

Thanks for this link. What do you all consider the best reishi to use?

Also, what doses for each? I'm on 2,000mg of PM per day. Budding the past few weeks, though nothing visible yet.

Swanson Red Reishi Extract was recommended somewhere.

I'm not an expert with doses. I started out with recommended label (a dropper to a dropper and a half) twice a day and am now at three times a day with both.

[Lotus]

The most potent was y-Linolenic acid, GLA-aka EPO-Evening Primrose Oil.

Maybe thats the reason why I did grow last year when I took EPO. I definitely will up my dose to two capsules now. Thanks Lotus.

I'm taking two too! Only for a couple weeks though

These oils target breast growth, madacamia, vitex, red clover targets ER-a (the growth receptor). The links provided are for fyi.

Coconut oil
http://www.amazon.com/Barleans-Organic-Virgin-Coconut-16-Ounce/dp/B002VLZ8D0/ref=sr_1_10?ie=UTF8&qid=1425050271&sr=8-10&keywords=coconut+oil

Cucumber oil
http://www.amazon.com/CUCUMBER-Undiluted-Pressed-Botanical-Beauty/dp/B00BX3RLD2/ref=sr_1_2?ie=UTF8&qid=1425049927&sr=8-2&keywords=cucumber+oil

Macadamia oil
http://www.amazon.com/Macadamia-Nut-Cold-Pressed-Liquid/dp/B0017OAHPQ/ref=pd_sbs_bt_1?ie=UTF8&refRID=0BAN3M7J6KP6K6V5CNMS

Nutmeg oil
http://www.amazon.com/Nutmeg-Essential-U...B005Y4CV72

Turmeric oil
http://www.amazon.com/Turmeric-100-Therapeutic-Grade-Essential/dp/B005CIK5U0/ref=pd_sim_bt_5?ie=UTF8&refRID=07KHAMV92SQF7DQVSZG5

Vitex extract
http://www.amazon.com/Natures-Answer-Alcohol-Free-Vitex-1-Fluid/dp/B00014F9YC/ref=sr_1_6/177-7490590-4453118?ie=UTF8&qid=1425065984&sr=8-6&keywords=chasteberry

Red clover oil
http://www.amazon.com/Natures-Answer-Alcohol-Free-Flowering-1-Fluid/dp/B0001VUXKU/ref=sr_1_3?s=hpc&ie=UTF8&qid=1425066423&sr=1-3&keywords=Red+clover+extract