curiously enough I've taken one per day for a while just to see what it would do. I figured I'd run out the last bottle this way. What I've noticed is nothing different. Then again there is more to NBE than one ingredient. I've never taken it as a sole ingredient in the program (which is currently coconut oil, fenugreek 2/day, maca 1/day, cla 2/day, 1 bo/day). I'd be doubtful it'd do anything. If you want to find out take one per day for three months and see if you notice anything. I've had no adverse side effects even when taking 6bo/day.