[Atom]

** fatty acid synthase (FASN) in (humans)

Gene ID: 2194, updated on 21-Mar-2015

The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
http://www.ncbi.nlm.nih.gov/gene/2194

More scientific proof that fatty acids helps with the binding process of estrogen receptor alpha (ER-a, the growth receptor). Specifically---palmitate (a solid unsaturated fat). I hope this is making sense for everybody. In other words- omega 3's and 6's needs to be in an NBE plan, the health benefits alone are worth looking into, another benefit is its ability to block DHT (e.g. Evening primrose oil, EPO).

Coconut oil
Evening primrose oil
Macadamia nut oil
Krill oil

And organic when possible.

Hi Lotus, I have seen a few times you mention Macadamia oil as binding to ER-a, or targets ER-a, or stimulates ER-a, I was wondering where you got that because I couldn't find anything online, I figured maybe it was a bit more complicated and had to do with specific aspects of Macadamia oil. Is this your explanation, if so I cannot understand what you are saying here, since there is no palmitate in Macadamia? Or was that part separate from the list of oils? If so, do you recommend taking palmitate? I was wondering if you could clarify what you mean about Macadamia targeting or binding or stimulating ER-a, as in why you say it, and how it works - do you mean if you ingest Macadamia oil your breasts and hips will grow faster then other oils? Or is this more about topical application which aids estrogen production in general? Or any use which aids estrogen in general?

[Lotus]

** fatty acid synthase (FASN) in (humans)

Gene ID: 2194, updated on 21-Mar-2015

The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
http://www.ncbi.nlm.nih.gov/gene/2194

More scientific proof that fatty acids helps with the binding process of estrogen receptor alpha (ER-a, the growth receptor). Specifically---palmitate (a solid unsaturated fat). I hope this is making sense for everybody. In other words- omega 3's and 6's needs to be in an NBE plan, the health benefits alone are worth looking into, another benefit is its ability to block DHT (e.g. Evening primrose oil, EPO).

Coconut oil
Evening primrose oil
Macadamia nut oil
Krill oil

And organic when possible.

Hi Lotus, I have seen a few times you mention Macadamia oil as binding to ER-a, or targets ER-a, or stimulates ER-a, I was wondering where you got that because I couldn't find anything online, I figured maybe it was a bit more complicated and had to do with specific aspects of Macadamia oil. Is this your explanation, if so I cannot understand what you are saying here, since there is no palmitate in Macadamia? Or was that part separate from the list of oils? If so, do you recommend taking palmitate? I was wondering if you could clarify what you mean about Macadamia targeting or binding or stimulating ER-a, as in why you say it, and how it works - do you mean if you ingest Macadamia oil your breasts and hips will grow faster then other oils? Or is this more about topical application which aids estrogen production in general? Or any use which aids estrogen in general?

Hi Atom,

This following inforamtion is only some of what I found on Macadamia nut oil, you simply find the bread trail to the answers. You'll find that macadamia nut oil is also used in cosmetics and other product enhancers.

** fatty acid synthase (FASN) in (humans)

Gene ID: 2194, updated on 21-Mar-2015

The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
http://www.ncbi.nlm.nih.gov/gene/2194

More scientific proof that fatty acids helps with the binding process of estrogen receptor alpha (ER-a, the growth receptor). Specifically---palmitate (a solid unsaturated fat). I hope this is making sense for everybody. In other words- omega 3's and 6's needs to be in an NBE plan, the health benefits alone are worth looking into, another benefit is its ability to block DHT (e.g. Evening primrose oil, EPO).

Coconut oil
Evening primrose oil
Macadamia nut oil
Krill oil

And organic when possible.

Polyunsaturated fats and prostaglandins stimulate the expression of aromatase, the enzyme that synthesizes estrogen.

Generally, ingested fats show up in adipose tissue depots and in the bloodstream (in lipoproteins or as FFA) and the ultimate storage site is determined by the places where blood flows the greatest. Women, for instance, store a greater proportion of ingested fats in the subcutaneous adipose tissue depots than men because of these regional blood flow differences (Jensen, Sarr, Dumesic, Southorn, & Levine, 2003).

In principle, on activation by the lipolytic hormones, short, polyunsaturated fats (e.g., linoleate) would be mobilized in preference to longer, saturated fats because they are more accessible to the water-soluble enzyme, HSL, which catalyzes the release of fatty acids from glycerol. (To add another layer of complexity, depending on the circumstances, adipose tissue depots contribute differentially to the blood FFA pool [Mittendorfer, Liem, Patterson, Miles, & Klein, 2003]). Nonetheless, in reality, on average, plenty of saturated (e.g., stearate and palmitate) and monounsaturated fats (e.g., oleate and palmitoleate) are released in addition to polyunsaturated fats, so when fats are mobilized a mixture is available for use as fuel by tissues elsewhere (Staiger et al., 2004).


http://www.andrewkimblog.com/2013/02/dr-...fe-of.html

activity of fatty acids.
Liu J1, Shimizu K, Kondo R.
Author information
1Department of Forest and Forest Products Science, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan.
Abstract
In this study, we show that 5alpha-reductase derived from rat fresh liver was inhibited by certain aliphatic free fatty acids. The influences of chain length, unsaturation, oxidation, and esterification on the potency to inhibit 5alpha-reductase activity were studied. Among the fatty acids we tested, inhibitory saturated fatty acids had C12-C16 chains, and the presence of a C==C bond enhanced the inhibitory activity. Esterification and hydroxy compounds were totally inactive. Finally, we tested the prostate cancer cell proliferation effect of free fatty acids. In keeping with the results of the 5alpha-reductase assay, saturated fatty acids with a C12 chain (lauric acid) and unsaturated fatty acids (oleic acid and alpha-linolenic acid) showed a proliferation inhibitory effect on lymph-node carcinoma of the prostate (LNCaP) cells. At the same time, the testosterone-induced prostate-specific antigen (PSA) mRNA expression was down-regulated. These results suggested that fatty acids with 5alpha-reductase inhibitory activity block the conversion of testosterone to 5alpha-dihydrotestosterone (DHT) and then inhibit the proliferation of prostate cancer cells.
PMID: 19353546 [PubMed - indexed for MEDLINE]




Elemental composition and chemical characteristics of five edible nuts (almond, Brazil, pecan, macadamia and walnut) consumed in Southern Africa

The total elemental concentrations and proximate chemical composition of five different tree nuts, almond (Prunus dulcus), Brazil (Bertholletia excelsa), pecan (Carya pecan), macadamia (Macadamia integrifolia) and walnut (Juglans nigra) that are consumed in South African households were investigated. In addition, six physicochemical properties of the extracted nut oils, namely acid value, iodine value, saponification value, refractive index, density and specific gravity were evaluated. A high concentration of Se (36.1 ± 0.4 μ g g− 1) was found in the Brazil nuts only. With maximum and minimum limits being set by the almond and pecan nut samples, Cr ranging from 0.94 ± 0.14–2.02 ± 0.07 μ g g− 1 was detected in the nut samples. Generally, the order of the concentrations of the elements in all the nut samples is found to be Mg > Ca > Fe > Cu > Cr > As > Se. The concentrations of Mn and Zn showed greater variation amongst the different types of nuts. The extracted oils showed low acid values and high saponification values with the macadamia nut sample having the highest oil content (76.0 ± 0.5 g per 100 g of sample), the lowest acid value (0.42 ± 0.01 mg KOH per g of oil) and highest saponification value (193.7 ± 2.4 mg KOH per g of oil). The present findings are useful in calculating the Dietary Reference Intakes of these nutrients.

Fatty acid profile, tocopherol, squalene and phytosterol content of walnuts, almonds, peanuts, hazelnuts and the macadamia nut.
Maguire LS1, O'Sullivan SM, Galvin K, O'Connor TP, O'Brien NM.
Author information
Abstract
Nuts are high in fat but have a fatty acid profile that may be beneficial in relation to risk of coronary heart disease. Nuts also contain other potentially cardioprotective constituents including phytosterols, tocopherols and squalene. In the present study, the total oil content, peroxide value, composition of fatty acids, tocopherols, phytosterols and squalene content were determined in the oil extracted from freshly ground walnuts, almonds, peanuts, hazelnuts and the macadamia nut. The total oil content of the nuts ranged from 37.9 to 59.2%, while the peroxide values ranged from 0.19 to 0.43 meq O2/kg oil. The main monounsaturated fatty acid was oleic acid (C18:1) with substantial levels of palmitoleic acid (C16:1) present in the macadamia nut. The main polyunsaturated fatty acids present were linoleic acid (C18:2) and linolenic acid (C18:3). alpha-Tocopherol was the most prevalent tocopherol except in walnuts. The levels of squalene detected ranged from 9.4 to 186.4 microg/g. beta-Sitosterol was the most abundant sterol, ranging in concentration from 991.2 to 2071.7 microg/g oil. Campesterol and stigmasterol were also present in significant concentrations. Our data indicate that all five nuts are a good source of monounsaturated fatty acid, tocopherols, squalene and phytosterols.

Hi all,

Here's some info I've put together on enhancing breasts (mostly skin application).


Stimulating lipid synthesis increases the volume of adipocytes (fatty tissues found in breasts). Avocado oil, emu oil are excellent carrier oils. Palmitoyl (Pentapeptide) aka -peptides, (see below), Caprylic/Capric Triglyceride, Dictyopteris Oil, are important for cellular binding and lipid synthesis. Macadamia nut oil stimulates estrogen receptor alpha (ER-a).

Fatty Acid and Lipid Synthesis
http://dwb4.unl.edu/Chem/CHEM869P/CHEM86...idSyn.html

Adipose Tissue: Not Just Fat
http://themedicalbiochemistrypage.org/ad...tissue.php

Acute in vitro production of acylation stimulating protein in differentiated human adipocytes
http://www.jlr.org/content/38/1/1.full.pdf

The three features of skin penetration enhancer activity (Lipid interaction, Protein alteration and Partitioning phenomena) represent the essential aspects of the LPP theory.

Lipid-protein-partitioning (LPP) theory of skin enhancer activity: finite dose technique
http://www.sciencedirect.com/science/art...7389902603

Cell Penetrating Peptides
http://wikipedia.org/wiki/Cell-penetrating_peptide

Ok, you remember what I said about palmitic acid being in estrogen receptor alpha (the boobie growth receptor?)

Well here you go, get happy!!

Dr. Duke's
Phytochemical and Ethnobotanical Databases


Plant parts with 5-alpha-reductase-inhibitor Activity
from the chemical PALMITOLEIC-ACID

Anacardium occidentale L. -- Cashew; found in Seed
Ananas comosus (L.) MERR. -- Pineapple; found in Fruit
Anethum graveolens L. -- Dill, Garden Dill; found in Fruit
Apium graveolens L. -- Celery; found in Pt
Aquilegia vulgaris L. -- Columbine; found in Seed
Arachis hypogaea L. -- Groundnut, Peanut; found in Seed
Areca catechu L. -- Betel Nut, Pin-Lang; found in Seed
Asparagus officinalis L. -- Asparagus; found in Shoot
Bactris gasipaes HBK. -- Peach palm, Pejibaye; found in Fruit
Bertholletia excelsa BONPL. -- Brazilnut, Brazilnut-Tree, Creamnut, Paranut; found in Seed
Brassica nigra (L.) W. D. J. KOCH -- Black Mustard; found in Leaf
Brassica oleracea var. gemmifera var. gemmifera DC -- Brussel-Sprout, Brussels-Sprouts; found in Leaf
Brassica oleracea var. gongylodes L. -- Kohlrabi; found in Stem
Brassica oleracea var. sabellica l. var. acephala DC -- Curly Kale, Kale, Kitchen Kale, Scotch Kale; found in Leaf
Brassica oleracea var. viridis l. L. -- Collards, Cow Cabbage, Spring-Heading Cabbage, Tall Kale, Tree Kale; found in Plant
Brassica rapa var. rapa -- Rapini, Seven-Top Turnip, Turnip; found in Root
Calendula officinalis L. -- Calendula, Pot-Marigold; found in Seed
Capsicum annuum L. -- Bell Pepper, Cherry Pepper, Cone Pepper, Green Pepper, Paprika, Sweet Pepper; found in Fruit
Capsicum frutescens L. -- Cayenne, Chili, Hot Pepper, Red Chili, Spur Pepper, Tabasco; found in Fruit
Carica papaya L. -- Papaya; found in Fruit
Carum carvi L. -- Caraway, Carum, Comino (Sp.), Comino de prado (Sp.), Kummel (Ger.); found in Fruit
Cedrus deodora LOUD. -- Deodar Cedar; found in Seed
Cicer arietinum L. -- Chickpea, Garbanzo; found in Seed
Cichorium intybus L. -- Chicory, Succory, Witloof; found in Root
Citrullus colocynthis -- Colocynth; found in Seed
Citrus aurantiifolia (CHRISTM.) SWINGLE -- Lime; found in Fruit
Citrus paradisi MacFAD. -- Grapefruit; found in Fruit
Citrus reticulata BLANCO -- Mandarin, Tangerine; found in Fruit
Citrus sinensis (L.) OSBECK -- Orange; found in Fruit
Corchorus olitorius L. -- Jew's Mallow, Mulukiya, Nalta Jute; found in Leaf
Coriandrum sativum L. -- Chinese Parsley, Cilantro, Coriander; found in Fruit
Cucurbita pepo L. -- Pumpkin; found in Flower, Fruit , Seed
Cucurbita spp -- Summer Squash; found in Fruit
Daucus carota L. -- Carrot; found in Root, Seed
Elaeis guineensis JACQ. -- African Oil Palm; found in Fruit
Fragaria spp -- Strawberry; found in Fruit
Ginkgo biloba L. -- Ginkgo, Maidenhair Tree; found in Seed
Glycine max (L.) MERR. -- Soybean; found in Seed
Hibiscus sabdariffa L. -- Acedera de Guinea (Sp.), Indian Sorrel, Jamaica Sorrel, Kharkadi, Malventee (Ger.), Red Sorrel, Rosa de Jamaica (Sp.), Rosella (Ger.), Roselle, Sereni (Sp.), Sorrel; found in Seed
Hordeum vulgare L. -- Barley, Barleygrass; found in Leaf
Jatropha curcas MIERS -- Physic Nut, Purging Nut; found in Seed
Lablab purpureus (L.) SWEET -- Bonavist Bean, Hyacinth Bean, Lablab Bean; found in Seed
Lactuca sativa L. -- Lettuce; found in Leaf
Lens culinaris MEDIK. -- Lentil; found in Seed
Lupinus albus L. -- White Lupine; found in Seed
Lycopersicon esculentum MILLER -- Tomato; found in Fruit
Macadamia spp -- Macadamia; found in Seed
Malus domestica BORKH. -- Apple; found in Fruit
Mangifera indica L. -- Mango; found in Fruit
Morus alba L. -- Sang-Pai-Pi, White Mulberry; found in Seed
Mucuna pruriens (L.) DC. -- Cowage, Velvetbean; found in Seed
Murraya sp -- None; found in Plant
Musa x paradisiaca L. -- Banana, Plantain; found in Fruit
Nelumbo nucifera L. -- Water Lotus; found in Rhizome
Origanum vulgare L. -- Common Turkish Oregano, European Oregano, Oregano, Pot Marjoram, Wild Marjoram, Wild Oregano; found in Plant
Papaver somniferum L. -- Opium Poppy, Poppyseed Poppy; found in Seed
Pastinaca sativa L. -- Parsnip; found in Root
Persea americana MILLER -- Avocado; found in Fruit
Phoenix dactylifera L. -- Date Palm; found in Seed
Pinus edulis ENGELM -- Pinyon Pine; found in Seed
Pinus pinea L. -- Italian Stone Pine, Pignolia; found in Seed
Pistacia vera L. -- Pistachio; found in Seed
Pisum sativum L. -- Pea; found in Fruit
Portulaca oleracea L. -- Purslane, Verdolaga; found in Herb
Prunus cerasus L. -- Sour Cherry; found in Fruit
Prunus domestica L. -- Plum; found in Fruit
Prunus dulcis (MILLER) D. A. WEBB -- Almond; found in Seed
Prunus persica (L.) BATSCH -- Peach; found in Fruit
Psidium cattleianum SABINE -- Strawberry Guava; found in Fruit
Psidium guajava L. -- Guava; found in Fruit
Pyrus communis L. -- Pear; found in Fruit
Ribes nigrum L. -- Black Currant; found in Fruit
Ribes rubrum L. -- Red Currant, White Currant; found in Fruit
Sambucus nigra L. -- Black Elder, Elder, European Alder, European Elder, European Elderberry; found in Seed
Schisandra chinensis (TURCZ.) BAILL. -- Chinese Magnolia Vine, Five-Flavor-Fruit, Magnolia Vine, Schizandra, Wu Wei Zi, Wu Wei Zu; found in Seed
Secale cereale L. -- Rye; found in Seed
Sesamum indicum L. -- Ajonjoli (Sp.), Beni, Benneseed, Sesame, Sesamo (Sp.); found in Seed
Simarouba glauca DC. -- Simaruba Bark; found in Seed
Sinapis alba L. -- White Mustard; found in Seed
Skimmia arborescens T. ANDERSON EX GAMBLE -- Skimmia; found in Seed
Solanum melongena L. -- Aubergine, Eggplant; found in Fruit
Solanum tuberosum L. -- Potato; found in Tuber
Spinacia oleracea L. -- Spinach; found in Plant
Terminalia catappa L. -- Indian Almond, Malabar Almond, Tropical Almond; found in Seed
Tetragonia tetragonioides (PALLAS) KUNTZE -- New Zealand Spinach; found in Leaf
Triticum aestivum L. -- Wheat; found in Plant
Vicia faba L. -- Broadbean, Faba Bean, Habas; found in Seed
Vigna unguiculata subsp. sesquipedalis (L.) VERDC. -- Asparagus Bean, Pea Bean, Yardlong Bean; found in Fruit, Seed , Shoot
Zea mays L. -- Corn; found in Fruit
Zingiber officinale ROSCOE -- Ginger; found in Rhizome

[Atom]

Thank you. So from all that besides Macadamia being anti-androgen and pro-aromatase, was their anything else we should know? Like I see you recommend it for topical use, does it do anything other then be anti-androgen and pro-aromatase there as well?

[Lotus]

Thank you. So from all that besides Macadamia being anti-androgen and pro-aromatase, was their anything else we should know? Like I see you recommend it for topical use, does it do anything other then be anti-androgen and pro-aromatase there as well?

Atom,

Please tell me why the interst in palmitate?, macadamia?, are you interested in or personally pursuing NBE?

Thanks

[Atom]

I am on an NBE plan for a little over 3 months (after starting and then stopping many years ago before PM was known about), and I am looking for an oil to use as a regular cooking oil that can also be helpful, since why not? And I saw what you said about Macadamia and didn't understand what you meant, like is it especially different from coconut oil or just similar? Appreciate that you are so responsive

[Lotus]

I am on an NBE plan for a little over 3 months (after starting and then stopping many years ago before PM was known about), and I am looking for an oil to use as a regular cooking oil that can also be helpful, since why not? And I saw what you said about Macadamia and didn't understand what you meant, like is it especially different from coconut oil or just similar? Appreciate that you are so responsive

Ok thanks, now I understand better.

Personally, I now believe coconut oil to be far superior to any other oils, that's just my opinion (here), but the science (scholarly) behind coconut oil can fill volumes compared to macadamia science. But the meat and potatoes is stimulating lipid synthesis, which increases the volume of adipocytes (fatty tissues found in breasts).

I've come to understand that saturated fats (C12-chains, C==C bond) are actually healthier than polyunsaturated fats. Maybe stimulating ER-aplha green lights growth too fast?, with any family history of cancer genes I'd avoid NBE altogether. Proceed with caution, get regular blood tests if possible, get approval from your GP, more universal breast protection safety needs to be practiced overall.

In principle, on activation by the lipolytic hormones, short, polyunsaturated fats (e.g., linoleate) would be mobilized in preference to longer, saturated fats because they are more accessible to the water-soluble enzyme, HSL, which catalyzes the release of fatty acids from glycerol. (To add another layer of complexity, depending on the circumstances, adipose tissue depots contribute differentially to the blood FFA pool [Mittendorfer, Liem, Patterson, Miles, & Klein, 2003]). Nonetheless, in reality, on average, plenty of saturated (e.g., stearate and palmitate) and monounsaturated fats (e.g., oleate and palmitoleate) are released in addition to polyunsaturated fats, so when fats are mobilized a mixture is available for use as fuel by tissues elsewhere (Staiger et al., 2004).

[Lotus]

Atom,

You might find these links useful on Coconut oil and estrogen receptors.

Coconut oil
http://raypeat.com/articles/articles/coconut-oil.shtml

Coconut Oil: This Cooking Oil Is a Powerful Virus-Destroyer and Antibiotic
http://articles.mercola.com/sites/articl...althy.aspx

Estrogen receptors (Ray Peat)
http://raypeat.com/articles/articles/pdf...xplain.pdf

___________________

I like this forum (products sold).
Lipo-filling (FAT) stimulation action on topicals
http://www.essentialdayspa.com/forum/vie...?tid=38009

[Atom]

Thanks a lot, looks like I have a bit of reading.

[charrr]

Girl, you know I am subscribed from way back! You haven't even seen a single image of my timid self anywhere on the site! I understand! I just wanted to make sure that is what was happening computer-wise. Now, just go back to impressing us like your getting payed for every jaw-drop you post.

[Lotus]

Char (our Boob Baroness)

I will be patiently waiting (don't hold my breath right?) for the day to come when you decide to post a pic. Even a covered boobie would be cool.

Here's my reference: the pics range from 6 to 18 months (roughly). I'll be adding some recent pics, (3yrs of progress).