(10-01-2016, 12:17 AM)Lotus Wrote: The lemon juice we've suggested (right POM) in the morning comes to mind, although now sounds like a good strategy for 2-3 times a day.---------------------------------------------------------------
(10-01-2016, 12:04 AM)Lotus Wrote:(09-01-2016, 08:51 PM)Tanya Marie Squirrel Wrote: Lol Lotus, this had become a very expansive thread. Is there any chance to get an updated version of all this wisdom in a condensed layman's version in here or in a project x (xtra thread)?. With ovr 300 pages, Gone With the Wind reads like a comic book compared to finding all your findings spread out . I know its a daunting task.
Its ok if you dont..just a request :p
Hmm, throws up a red flare, yes, I have though about it. Daunting? (Sheesh) damn near impossible I thinks, I'd need help.
(10-01-2016, 12:01 AM)Lotus Wrote: I've done more digging on PM too, (nod to xxd, he'll know what I mean). For instance, I still have an issue with my eye from when I used BO, (pressure and excess tear duct flow) it messes with me vision, aye!. (Plays tricks on me, e.g. typing lol)anyways.......I find that PM induces expression of the enzyme CYP1B1, which is active in many tissues, including structures of the eye.
Pm induces the expression of the enzyme CYP1B1 (which is explained as follows)
The function of the CYP1B1 enzyme in the development of the eye is unclear, but it may play a role in forming structures at the front of the eye and may also be involved in a process that regulates the secretion of fluid inside the eye.
http://ghr.nlm.nih.gov/gene/CYP1B1
Quote:CYP1B1 was induced by deoxymiroestrol, in which the gene expressions were time- and concentration-dependent patterns compared to those of estradiol.
Now, I also see this as an explanation of the optic migraines (jannet and others), which lead to glaucoma. Hint, I believe this has already been seen in a few cases here.
miroestrol and deoxymiroestrol might affect hepatic P450 enzymes, including the CYP2B9 and CYP1A2 P450 isoforms. More on this upcoming: it'll surprise you (about PM)
(10-01-2016, 03:32 PM)Tanya Marie Squirrel Wrote:(10-01-2016, 12:04 AM)Lotus Wrote:(09-01-2016, 08:51 PM)Tanya Marie Squirrel Wrote: Lol Lotus, this had become a very expansive thread. Is there any chance to get an updated version of all this wisdom in a condensed layman's version in here or in a project x (xtra thread)?. With ovr 300 pages, Gone With the Wind reads like a comic book compared to finding all your findings spread out . I know its a daunting task.
Its ok if you dont..just a request :p
Hmm, throws up a red flare, yes, I have though about it. Daunting? (Sheesh) damn near impossible I thinks, I'd need help.
Lol I dub this thread The Lotus Lexicon of NBE... or perhaps the Lotus Library
(10-01-2016, 05:06 PM)iaboy Wrote:(10-01-2016, 12:01 AM)Lotus Wrote: I've done more digging on PM too, (nod to xxd, he'll know what I mean). For instance, I still have an issue with my eye from when I used BO, (pressure and excess tear duct flow) it messes with me vision, aye!. (Plays tricks on me, e.g. typing lol)anyways.......I find that PM induces expression of the enzyme CYP1B1, which is active in many tissues, including structures of the eye.
Pm induces the expression of the enzyme CYP1B1 (which is explained as follows)
The function of the CYP1B1 enzyme in the development of the eye is unclear, but it may play a role in forming structures at the front of the eye and may also be involved in a process that regulates the secretion of fluid inside the eye.
http://ghr.nlm.nih.gov/gene/CYP1B1
Quote:CYP1B1 was induced by deoxymiroestrol, in which the gene expressions were time- and concentration-dependent patterns compared to those of estradiol.
Now, I also see this as an explanation of the optic migraines (jannet and others), which lead to glaucoma. Hint, I believe this has already been seen in a few cases here.
miroestrol and deoxymiroestrol might affect hepatic P450 enzymes, including the CYP2B9 and CYP1A2 P450 isoforms. More on this upcoming: it'll surprise you (about PM)
So, if I catch or boil down the $15 words, your suggesting that PM would or could cause irreparable damage to eyes???? So then, we are screwed either way we go... Pharma E can cause cancer's, DVT and promote other nasty's ..
Quote:It is not well understood how defects in the CYP1B1 enzyme cause signs and symptoms of glaucoma. Recent studies suggest that the defects may interfere with the early development of the trabecular meshwork, which is a network of mesh-like canals that helps drain excess fluid from the eye. If fluid cannot be drained, pressure inside the eye may increase, which is characteristic of glaucoma.