[elainecd]

peony root extract has helped my areolas both in size and color. At least I think they have. If I don't do it once a day they def go back smaller.

[Lotus]

peony root extract has helped my areolas both in size and color. At least I think they have. If I don't do it once a day they def go back smaller.

Cool,

White peony inhibits the 5 alpha reductase enzyme (from the conversion to DHT) in the sebaceous glands, which produces sebum. Sebaceous glands are bunched around the areolas, a topical solution would work too, imo. But, I'd add a pro-aromatase, pro-ERa like red clover. I've done this before and blew up my areolas.

Thanks Elaine, good to hear from you.

[jannet.duff]

peony root extract has helped my areolas both in size and color. At least I think they have. If I don't do it once a day they def go back smaller.

Cool,

White peony inhibits the 5 alpha reductase enzyme (from the conversion to DHT) in the sebaceous glands, which produces sebum. Sebaceous glands are bunched around the areolas, a topical solution would work too, imo. But, I'd add a pro-aromatase, pro-ERa like red clover. I've done this before and blew up my areolas.

Thanks Elaine, good to hear from you.

Did the areolas stay that big if you dropped the red clover?

[Lotus]

peony root extract has helped my areolas both in size and color. At least I think they have. If I don't do it once a day they def go back smaller.

Cool,

White peony inhibits the 5 alpha reductase enzyme (from the conversion to DHT) in the sebaceous glands, which produces sebum. Sebaceous glands are bunched around the areolas, a topical solution would work too, imo. But, I'd add a pro-aromatase, pro-ERa like red clover. I've done this before and blew up my areolas.

Thanks Elaine, good to hear from you.

Did the areolas stay that big if you dropped the red clover?

They fluctuate from medium to large. Oddly, when I tweak with T they expand too. But, you've all seen crazy hairs popping from areolas right?. Well, this is what I mean about how WP helps battle DHT in the areolas.

[Atom]

Have you seen this study?

Androgen Modulators from the Roots of Paeonia lactiflora (Paeoniae
Radix) Grown and Processed in Nara Prefecture, Japan
Kazuto W ASHIDA ,* , a Yoshiyuki I TOH , b Takashi I WASHITA , b and Kyosuke N OMOTO a

https://www.jstage.jst.go.jp/article/cpb...9_971/_pdf

We have thus isolated the first hormone modulators from
the roots of P. lactiflora. This is the first report of paeoni-
florin and albiflorin derivatives such as 1, 2, 4 and 5 showing
AR binding activity. Interestingly, compounds 6 and 7
showed no AR binding activity. The AR binding activity of
6-O-galloylalbiflorin (2) was much stronger than that of the
galloylpaeoniflorin derivatives (1, 5). These results suggested
that both the structure of albiflorin and the galloyl moiety
were important for 2 to show strong AR binding activity. Ad-
ditionally, 6-O-galloylpaeoniflorin (5) displayed the weakest
AR binding activity of the paeoniflorin derivatives (1, 4, 5).
The only structural differences between 2 and 5 are at C-4
and C-9, so the galloyl moiety of 2 might interact with the
carbonyl group of C-9 and/or the hydroxyl group of C-4.
It has been reported that 3 can inhibit growth of prostate
cancer LNCaP cells by two aspects including inhibition of 5-
a -reductase activity and expression of AR protein levels;
however, the AR binding activity of 3 has not been re-
ported. 12) We propose that 3 inhibits prostate cancer cell
growth partly by acting as an AR antagonist.
The AR binding activity of compound 3 was equivalent to
flutamide (IC 50 5.0 m M ), 13) which is in clinical use, and the
activity of compound 2 was also relatively strong. Additon-
ally, because Paeoniae radix was taken in long time as a
crude drug, compounds 2 and 3 might be candidates as safe,
natural AR antagonists.

[Atom]

Peony root, besides being good for NBE, was also a favored plant of one of the top Chinese herbalists from long ago who was instrumental in the development of Chinese traditional medicine, and it is widely used in Chinese traditional medicine for cramps and arthritis pain - it is known as an antibacterial, antifungal, analgesic, sedative, anti-spasmodic, and anti-inflammatory. I can attest to it's strength in some of those areas, I was having some inflammation based jaw pain maybe due to an arthritic flare up that wouldn't go away, I had been out of peony and when I got some it immediately got rid of the inflammation and pain, something NSAIDS and vicodin were unable to do. It is a very powerful herb in those areas I just mentioned. But red peony may be more effective in some ways then white peony from what I have read. Red peony is the same root as white peony but with the skin still on. In one study I read they concluded that red peony has more paeoniflorin which seems to be anti-inflammatory. Another thing, I have used the dried root, alcohol extract, and powdered extract. The powdered extract had no flavor while the root is very bitter, which it is known for. Out of the three the root itself seemed stronger, and that seems to be what the research has found when they studied the processed vs. unprocessed forms. As I have learned from studying herbal extracts, not all constituents of plants can be extracted, some plants are best consumed whole because of that.

[Lotus]

That's a great find Atom, (thanks)

It looks like 6 -O-galloylalbiflorin and pentagalloylglucose acts like flutamide (a strong non-steroidal anti-androgen), but flutamide carries hepatic risks (toxicity). Aside from the health benefits of WP, the fact it inhibits human prostate cancer cells is a major find.



So, in ovaries WP promotes aromatase, (I believe in the breasts too), inhibits DHT in sebum, inhibits prostate cancer cells, (which means it inhibits C17 @ CYP17 P450 enzyme, a strong anti-androgen. The lab dosage was 2 grams (I'll have to double check). Roots be king.

[Lotus]

peony root extract has helped my areolas both in size and color. At least I think they have. If I don't do it once a day they def go back smaller.

Cool,

White peony inhibits the 5 alpha reductase enzyme (from the conversion to DHT) in the sebaceous glands, which produces sebum. Sebaceous glands are bunched around the areolas, a topical solution would work too, imo. But, I'd add a pro-aromatase, pro-ERa like red clover. I've done this before and blew up my areolas.

Thanks Elaine, good to hear from you.

I think lemon and orange peel could work too, try it. the fact they inhibit DHT (CYP17 inhibitor) makes sense too.

In conclusion, we suggest in the present study that the supplementation with lemon polyphenols suppressed body weight gain and body fat accumulation by increasing the peroxisomal β-oxidation, which was likely mediated via up-regulation of the mRNA levels of PPARα in the liver. In addition, the levels of serum insulin, glucose and leptin were significantly improved by lemon polyphenols, thereby improving the insulin resistance. We suggest that a supplementation with lemon polyphenols may prevent or improve obesity and insulin resistance by modulating lipid metabolism and preventing metabolic syndrome as a representative, lifestyle-related cluster of diseases caused by an excessively high fat diet.

Lemon Polyphenols Suppress Diet-induced Obesity by Up-Regulation of mRNA Levels of the Enzymes Involved in β-Oxidation in Mouse White Adipose Tissue
http://www.ncbi.nlm.nih.gov/pmc/articles...43-201.pdf

[Lotus]

It would be nice to have a complete diagram of a breast with how all these hormones work, in the meantime, draw a silhouette of a boob and put this diagram in it.

The Adrenal pathway noted can be related to male breast growth pathway (via the androstenedione pathway-@ E1-E2).

[Marcy]

[/quote]

They fluctuate from medium to large. Oddly, when I tweak with T they expand too. But, you've all seen crazy hairs popping from areolas right?. Well, this is what I mean about how WP helps battle DHT in the areolas.


[/quote]

Lotus, can you check that image link? It's not showing up for me. Thanks!
Edit - got it now. Thanks! Beautiful : )