Understanding the bioavailability of polyphenols as it relates to metabolism helps us to understand their role with NBE. In other words, know how your body handles the NBE supplements you take. Start slow/go slow........one thing we've seen is how everyone is different, meaning one person can handle one thing while another can't, BO is a classic example.
(Genetic differences in the P-450 enzymes can result in abnormal reactions to drugs, including idiosyncratic reactions).
http://emedicine.medscape.com/article/16...verview#a1
Use common sense when approaching NBE. Why do we start of with 8-12 tablets of BO or 3000 mg of PM and think nothing off it?. Don't underestimate the harm of supplementing with NBE, we've seen (here) too many examples of injury. Use quality (standardized) products that with come with a guarantee. When possible look at being monitored by healthcare professionals that will run labs, vitals, give recommendations etc.
Look at related studies with an open mind, (it's subjective) then formulate your own decision. Stay vigilant, know your body, look for warning signs of toxicity, (nausea, diarrhea, headache, fatigue, heavy bleeding etc). I drink water alongside coffee/tea, and for every sip of either I follow with cold (iced) lemon water (and in my opinion) helps with the bioavailability. Do a liver detox monthly......
Toxic hepatitis occurs when your liver develops inflammation because of exposure to a toxic substance. Toxic hepatitis may also develop when you take too much of a prescription or over-the-counter medication.
One of the liver's roles involves removing and breaking down most drugs and chemicals from your bloodstream. Breaking down toxins creates byproducts that can damage the liver. Although the liver has a great capacity for regeneration, constant exposure to toxic substances can cause serious, sometimes irreversible harm.
Toxic hepatitis can be caused by:
* Alcohol. Heavy drinking over many years can lead to alcoholic hepatitis — inflammation in the liver due to alcohol.
* Over-the-counter pain relievers. Nonprescription pain relievers such as acetaminophen (Tylenol, others), aspirin, ibuprofen (Advil, Motrin IB, others) and naproxen (Aleve, others) can damage your liver, especially if taken frequently or combined with alcohol.
* Prescription medications. Some medications linked to serious liver injury include the combination drug amoxicillin-clavulanate (Augmentin), halothane, isoniazid, valproic acid (Depakene), phenytoin (Dilantin, Phenytek), azathioprine (Azasan, Imuran), niacin (Niaspan), atorvastatin (Lipitor), lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor), fluvastatin (Lescol), rosuvastatin (Crestor), ketoconazole, certain antibiotics, certain antivirals and anabolic steroids. There are many others.
* Herbs and supplements. Some herbs considered dangerous to the liver include cascara, chaparral, comfrey, kava and ephedra. There are many others. Children can develop liver damage if they mistake vitamin supplements for candy and take large doses.
* Industrial chemicals. Chemicals you may be exposed to on the job can cause liver injury. Common chemicals that can cause liver damage include the dry cleaning solvent carbon tetrachloride, a substance used to make plastics called vinyl chloride, the herbicide paraquat and a group of industrial chemicals called polychlorinated biphenyls.
http://www.mayoclinic.org/diseases-condi...N-20026939
Is Green Tea Good for You & How Much Can You Drink Daily?
Daily Intake
The potency of green tea varies from brand to brand, as does the potential for toxicity from excessive use. An overdose of green tea can lead to liver damage and other unpleasant side effects. To maximize the health benefits of green tea safely, the UMMC recommends drinking 2 to 3 cups daily, giving you 240 to 320 milligrams of polyphenols. If you take green tea extract supplements, 100 to 750 milligrams per day is recommended. Opt for caffeine-free products when possible. Because few studies have been done on green tea's effects on children, it is safest not to give it to them.
http://healthyeating.sfgate.com/green-te...-8620.html
Tea and Cancer Prevention
Among their many biological activities, the predominant polyphenols in green tea―EGCG, EGC, ECG, and EC―and the theaflavins and thearubigins in black teas have antioxidant activity (12). These chemicals, especially EGCG and ECG, have substantial free radical scavenging activity and may protect cells from DNA damage caused by reactive oxygen species.
Tea as a food item is generally recognized as safe by the U.S. Food and Drug Administration. Safety studies have looked at the consumption of up to 1200 mg of EGCG in supplement form in healthy adults over 1- to 4-week time periods (17, 18). The adverse effects reported in these studies included excess intestinal gas, nausea, heartburn, stomach ache, abdominal pain, dizziness, headache, and muscle pain (17, 18). In a Japanese study, children aged 6 to 16 years consumed a green tea beverage containing 576 mg catechins (experimental group) or 75 mg catechins (control group) for 24 weeks with no adverse effects (19). The safety of higher doses of catechins in children is not known.
http://www.cancer.gov/about-cancer/cause...fact-sheet
Green tea
http://umm.edu/health/medical/altmed/herb/green-tea
Metabolism of polyphenols occurs via a common pathway (83). The aglycones can be absorbed from the small intestine. However, most polyphenols are present in food in the form of esters, glycosides, or polymers that cannot be absorbed in their native form. These substances must be hydrolyzed by intestinal enzymes or by the colonic microflora before they can be absorbed. When the flora is involved, the efficiency of absorption is often reduced because the flora also degrades the aglycones that it releases and produces various simple aromatic acids in the process. During the course of absorption, polyphenols are conjugated in the small intestine and later in the liver. This process mainly includes methylation, sulfation, and glucuronidation. This is a metabolic detoxication process common to many xenobiotics that restricts their potential toxic effects and facilitates their biliary and urinary elimination by increasing their hydrophilicity. The conjugation mechanisms are highly efficient, and aglycones are generally either absent in blood or present in low concentrations after consumption of nutritional doses. Circulating polyphenols are conjugated derivatives that are extensively bound to albumin. Polyphenols are able to penetrate tissues, particularly those in which they are metabolized, but their ability to accumulate within specific target tissues needs to be further investigated. Polyphenols and their derivatives are eliminated chiefly in urine and bile. Polyphenols are secreted via the biliary route into the duodenum, where they are subjected to the action of bacterial enzymes, especially β-glucuronidase, in the distal segments of the intestine, after which they may be reabsorbed. This enterohepatic recycling may lead to a longer presence of polyphenols within the body.
http://m.ajcn.nutrition.org/content/79/5/727.full
Which Drugs are Harmful to Your Kidneys? - The National Kidney Foundation
https://www.kidney.org/atoz/content/Drugs-Your-Kidneys
Nipples are still über sensitive! I haven't been sleeping all that great,