[Lotus]

Thanks for the link Jamie.

____________________________________



Milk Thistle increased milk production by 85.94% in this study below. Btw, blessed thistle may increase stomach acid, be careful there.

Clinical efficacy, safety and tolerability of BIO-C (micronized Silymarin) as a galactagogue
Di Pierro F1, Callegari A, Carotenuto D, Tapia MM.
Author information
Abstract
BACKGROUND AND AIM OF THE WORK:
The authors have previously reported the use of Silymarin (a Silybum marianum standardized extract) as a promoter of milk production in cows. Due to the important psychological impact of hypogalactia in women after delivery, we evaluated the role of Silymarin as a safe and effective galactogogue for human species.
METHODS:
50 healthy women during lactation were enrolled in order to verify the galactogogue role played by an oral treatment with micronized Silymarin (420 mg/day) in comparison with an undistinguishable placebo product.
RESULTS:
Women orally treated for 63 days with Silymarin showed a clear galactagogue role for the product with an increase of 85.94% of the daily milk production (placebo: +32.09%). No drop out, nor unwanted effects were reported in both groups. Compliance and tolerability were also very good.
CONCLUSIONS:
Silymarin may be considered as a safe and effective herbal product that can be orally administered in order to improve the daily milk production in healthy women after delivery, without affecting milk quality.
PMID: 19260380

[ellacraig]

And liver protection too right?

wow.. i never saw that one!

[myboobs]

Thanks for the link Jamie.

____________________________________



Milk Thistle increased milk production by 85.94% in this study below. Btw, blessed thistle may increase stomach acid, be careful there.

Clinical efficacy, safety and tolerability of BIO-C (micronized Silymarin) as a galactagogue
Di Pierro F1, Callegari A, Carotenuto D, Tapia MM.
Author information
Abstract
BACKGROUND AND AIM OF THE WORK:
The authors have previously reported the use of Silymarin (a Silybum marianum standardized extract) as a promoter of milk production in cows. Due to the important psychological impact of hypogalactia in women after delivery, we evaluated the role of Silymarin as a safe and effective galactogogue for human species.
METHODS:
50 healthy women during lactation were enrolled in order to verify the galactogogue role played by an oral treatment with micronized Silymarin (420 mg/day) in comparison with an undistinguishable placebo product.
RESULTS:
Women orally treated for 63 days with Silymarin showed a clear galactagogue role for the product with an increase of 85.94% of the daily milk production (placebo: +32.09%). No drop out, nor unwanted effects were reported in both groups. Compliance and tolerability were also very good.
CONCLUSIONS:
Silymarin may be considered as a safe and effective herbal product that can be orally administered in order to improve the daily milk production in healthy women after delivery, without affecting milk quality.
PMID: 19260380

Very interesting

[Lotus]

And liver protection too right?

Yes, good point. Milk Thistle is also hepatoprotective, and anti-inflammatory.


Milk thistle and the treatment of hepatitis.
http://www.ncbi.nlm.nih.gov/pubmed/11847735

[Lotus]

Very interesting

Indeed.

[hannah]

Hey Lotus, you have been raising my interest with that new combination Epo+peanut oil..you said it opened new receptors? Please tell me more, how do we use this nutty combination?:p

[Lotus]

Hey Lotus, you have been raising my interest with that new combination Epo+peanut oil..you said it opened new receptors? Please tell me more, how do we use this nutty combination?:p

Oh that nutty combo? , (yes, here it is). First, heads up to peanut allergy suffers, alternatively, replacing with an omega 3 supplement is an option in my opinion, my choice of omega 3 option would be krill oil instead of peanut oil.

I think peanut oil works because it contains resveratrol (a known aromatase) and nitric oxide (a second messenger, aka promotes DNA synthesis). EPO (evening primrose oil) inhibits DHT and is a pro-aromatase. Signaling pathways are very interesting, they involve hormones (sex streiods), fatty acids, enzymes (e.g. Acetyl coenzyme A or acetyl-CoA) etc, understanding these pathways helps us to understand how relates to NBE (hrt too)..........and yes it's very complicated, to me it's worth investigating.

Both linoleate and arachidonate can activate Type-II and Type-III protein kinase-C in MEC

translation—linoleate (i.e. evening primrose oil) and arachidonate (i.e. peanut oil) improves cellular affinity of mammary epithelial.....aka milk duds, I mean milk ducts. though do add calcium with this combination, it activates the proteins.

Peanut oil (a DIY home method to make peanut oil is included).
http://articles.mercola.com/herbal-oils/peanut-oil.aspx

Ok, now we're making some progress, "linoleic acid (18:2 omega 6) and prostaglandin E2 or cAMP has synergistic effect on EGF-stimulated growth".

(Linoleic acid is evening primrose oil.)

What is epidermal growth factor?
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.
Epidermal growth factor receptor - Wikipedia, the free encyclopedia
Wikipedia › wiki › Epidermal_growth_f...


transducers: amplification of signals from growth factor receptors by fatty acids in mammary epithelial cells.

Abstract
The growth, morphogenesis and differentiation of milk producing epithelial tissues in the developing mammary glands require interaction with extracellular matrices and stimulation by hormones, growth factors and essential fatty acids. In primary culture, the proliferation of mammary epithelial cells (MEC), induced by epidermal growth factor (EGF), is enhanced and sustained by linoleate and its eicosanoid metabolites. Since a combination of linoleic acid (18:2 omega 6) and prostaglandin E2 or cAMP has synergistic effect on EGF-stimulated growth, it is suggested that additional cAMP-dependent protein kinase A (PK-A) independent pathways may also contribute to the linoleate effect on EGF action. Possible involvement of Ca2+/phospholipid-dependent protein kinase C (PK-C) is explored. Both linoleate and arachidonate can activate Type-II and Type-III protein kinase-C in MEC and a PK-C inhibitor can block growth stimulation by EGF and fatty acids. Like 12-O-Tetradecanoly phorbol-13-acetate (TPA), a PK-C activator which also enhances EGF-stimulated growth of MEC, linoleate can phosphorylate a 40-42 KD protein. EGF itself can stimulate transient phosphorylation of the same protein in MEC cultures but when supplemented with linoleate, which does not influence the ligand binding affinity of EGF-receptors, the transient phosphorylation signal in 40-42 KD protein is sustained.(ABSTRACT TRUNCATED AT 250 WORDS)

http://www.ncbi.nlm.nih.gov/pubmed/8424125

[ellacraig]

Hi L
So would this help me and my project?

[hannah]

Thanks a lot Lotus for revealing this to us....this sounds awesome But how do we take it? How much mgs do we need to supplement with? Or do we add the oil externally? And then you also mention calcium.. do we just drink milk or do we need lots of it? And then the last question when exactly do we take this? Daily or whenever you like? Or cycled? Or before sleep? Thanks again,you're awesome at this stuff!

[Lotus]

Hi L
So would this help me and my project?

Hi Ella,

I think if you maintain a balance of omega 6 to omega 3 (1:1 minimum ratio) it would help. Though increasing omega 3's could be of more benefit too (example @ 1:3 ratio). The EPO/peanut/calcium should help build back up milk supply, (have you added milk thistle?).