[Lotus]

 So glad to hear from you xxxx
 

Awe thanks, and so glad to hear from you Ella, hugs.

That’s really interesting re the morninga! I feel stupid I have some organic morninga here I’ve been forgetting to take !

You remember Bustybride? She had huge bosom. Remember her secret.. Aloe

Question: Is there any benefit to adding fenugreek as James says to the Aloe? 
Is there any benefit to suction therapy to AID the aloe? or the Aloe more aids in repair after suction?

Looking forward to hearing the rest of your research re the antivirals . It would be so good if instead of global suppressing of natural health we were given the chance to learn about natural antivirals and let the world get on with it instead of locking us all away.

Hi Ella, pull up a chair, grab some popcorn cause this thread is deep. I apologize in advance for the complexity of this post. 

I do remember bustybride, and to her credit and tenacity using aloe vera paid off for her.

As far as antivirals go the polysaccharides in aloe along with its anthraquinones are in fact " antivirals ".

kaempferol (flavonoid) is –6.2 kcal/mol, and for anthraquinone –6 kcal/mol. Visualization of the docking complex, important effects are observed regarding the binding of peptides to drug compounds. In conclusion, it is proposed that these compounds are effective antiviral agents against COVID-19 and can be used in clinical trials.

Now you see kaempferol named in that study right?, well...Red Clover has kaempferol. There's a 94.6% (or higher in some studies) homology from SARS-CoV to SARS-CoV-2...which is now named nCOV-2019. And if you remember from the earlier post this link:

nCOV-19 peptides mass fingerprinting identification, binding, and blocking of inhibitors flavonoids and anthraquinone of Moringa oleifera and hydroxychloroquine
https://www.tandfonline.com/doi/full/10....20.1778534

 
And so I see hydroxychloroquine HCQ a derivative of Chloroquine prescribed for the treatment of autoimmune diseases and anti-inflammatory agents is more virulent than chloroquine (in layman's terms it comes with side effects). But given a choice (personally) I'd choose the herbal anthraquinone (aloe, moringa, quercetin, etc) over hydroxychloroquine, but that's just me. But, anthraquinone needs to be taken on an empty stomach, it's gonna make you poop..a lot, but hey guess what?, so does consuming (soaked) fenugreek seeds (and the tea form too). 

A protein sequence analysis showed that the amino acid similarity of the seven conserved nonstructural proteins between SARS-CoV-2 and SARS-CoV was 94.6%, suggesting that they might belong to the same species.


A partial listing of herbal and food antivirals:
Rhubarb (stems)
Aloe
Moringa
Watercress 
Chrysin
Baicalein (sweet basil)
Myricetin
Scutellarein
Apigenin
Luteolin (like in tangerine or from hesperetin)
Quercetin
 
Among the various active components of Aloe are anthraquinones; chromones; monosaccharides; polysaccharides; vitamins B1, B2, B6, and C; niacinamide; choline and enzymes like acid and alkaline phosphatase; amylase; lactate dehydrogenase; lipase; and many inorganic ingredients, but most important among them is the long chain of acetylated mannose (Hayes 1999; Djeraba and Quere 2000).

Anthraquinones modulate autophagy, and if you're unfamiliar with autophagy, its description simply means it's the body's way of cleaning out damaged cells, in order to regenerate newer ones. Now normally you have to fast for 18-20 hours before autophagy kicks in and goes into high gear at 48 to 72 hours. Does this mean autophagy is useful for covid19?, it certainly doesn't hurt cleaning out damaged cells. What the science is saying that taking antivirals (e.g. anthraquinones) helps to minimize the risks of contracting covid19. 

Anthraquinones and autophagy – Three rings to rule them all?
https://www.sciencedirect.com/science/ar...9619305292


The anticancer activity of A. vera gel cnamely glycoproteins present in the gel, have antiulcer and antitumor activities (Yagi et al. 2003).

Fenugreek is useful for not just NBE, but for diabetics too. See the compounds in Fenugreek lowers blood sugar...and quite fast too. So by lowering blood sugars it helps people lose weight because insulin is lowered. So this is a two fold process with any insulining lowering agent. First, insulin is lowered which stems the tide of Testosterone production from insulin spikes. Metformin does exactly that, lowers insulin and inhibits T. But it also triggers AMPK production which helps in reducing belly fat and increases ATP to the mitochondria...and that's exactly what we want in breast growth (increasing ATP production). But...PDE (Phosphodiesterase) inhibits the increased ATP production synthesis. So I prefer Forskolin because it inhibits PDE production, lowers blood sugar, so if you have hashimoto's it has the potential to reverse it like it did for me. Plus its pro-aromatase stemming from the lowering of insulin (through the above described scenario). 

So, I see fenugreek as a lesser herbal version of metformin. It's useful for NBE, just not in my protocol. 

[Troublewithnibbles]

So forskolin will inhibit PDE without the help of other PDE inhibitors?

[Lotus]

So forskolin will inhibit PDE without the help of other PDE inhibitors?

It does, but there's another phosphodiesterase inhibitor I find interesting...aloe vera. 
https://www.researchgate.net/publication/256539509_Chemical_constituents_of_Aloe_barbadensis_Miller_and_their_inhibitory_effects_on_phosphodiesterase-4D

Somatostatin inhibits oral estradiol, prolactin, growth hormone and stomach gastrin. 

Somatostatin stimulates insulin, which has deleterious effects to breast growth. So, the new goal needs to inhibit somatostatin. Somatostatin also inhibits the cAMP/PKA/CREB pathway...which is the breast growth pathway. 

More info to follow bringing all this into focus.

[Stevenator.]

>More info to follow bringing all this into focus.

AWOO!

[Lotus]

>More info to follow bringing all this into focus.

AWOO!

Ok so bringing this into focus. A few years ago I posted some information (shared below) regarding cimetidine and how it inhibits stomach gastrin and thereby increases estradiol. Cimetidine and H2 inhibitors aren't the only game in town that inhibits gastrin. Forskolin and aloe vera and some other agents inhibit gastrin. Explaining what somatostatin does is explained in the link below. Trust me when I say somatostatin is about as bad for breast growth as DHT. In closing, inhibiting somatostatin seems to up our game for promoting breast growth. One final note about forskolin, it improves thyroid function, so much so in my case it reversed my hashimoto's of 15 years.

Somatostatin 
http://www.vivo.colostate.edu/hbooks/pat...tatin.html

Using H2 Blockers (H2-receptor antagonists) and to a lesser extent H1 receptors antagonists block stomach acid (aka. gastrin) increase plasma estradiol and prolactin.  Drugs like cimetidine and ranitidine (others too) inhibit stomach acid, though ranitidine to a lesser extent nukes the cytochrome (CYP) P450 enzymes. Cimetidine is for a short time (I believe 2-4weeks) to treat stomach acid. If you have normal stomach acid cimetidine and the like aren't necessary, as always consult a health professional.

https://www.breastnexum.com/showthread.php?tid=17436&pid=196127&highlight=cimetidine#pid196127
Post # 3990..

This study demonstrates that the administration of cimetidine to men decreases the 2-hydroxylation of estradiol and results in an increase in the serum estradiol concentration.

The Effects of Cimetidine on the Oxidative Metabolism of Estradiol
https://www.researchgate.net/publication..._Estradiol

[Troublewithnibbles]

And how exactly do we inhibit somatostatin?  I read this multiple times and didn’t pick up on that bit.

[Stevenator.]

Bad Link on the Cimetidine. 
What dosage levels are you referring to with Tagamet?

[Lotus]

And how exactly do we inhibit somatostatin?  I read this multiple times and didn’t pick up on that bit.

Melatonin and Phosphatidylcholine or Alpha GPC or CDP-choline help to inhibit somatostatin. Melatonin is 1-3mg and alpha GPC at 1200mg. I'm looking into a few other options too, I'll post that info when I find out more.

[Lotus]

Bad Link on the Cimetidine. 
What dosage levels are you referring to with Tagamet?

400mg, stay away from using cimetidine to boost estradiol...it's not worth the side effects.
https://pubmed.ncbi.nlm.nih.gov/2747769/

[Stevenator.]

I did a deep dive into Cimetidine last year, reading countless research articles about the stuff, but this paper is new to me. It’s quite an interesting drug, with tons of side effects and properties. Thank you.