Dear Lotus, and friends;

  I found out Peony, and Licorice both reduce the production of testosterone. We know Licorice raises blood presure, but they make a DGL Licorice that might help for desperate DIY'ers.

    Blessings,

    Steffy Anne

Faith + Hope + Love >

Love and Joy and Peace

Hey Steffy Anne

You may want to take a look at Lotus whole thread, i know it's huge but it's super interesting to see Lotus' ideas and knowledge morph as the research comes in and the data gets applied to NBE. I say this because i vaguely remember Licorice being written about, it may save you some research time of your own, but be sure to keep reading as some ideas are dropped further on in the thread because new research dismisses  the original idea.

Bonny x

Thank you Bonny:

    I have found a lot of advice from this thread, and Lotus's thread on Antiandrogens helpful, and some older advice that crippled my ability to accomplish a fully developed transition, so that is why I asked Lotus for her current info on reducing the production of testosterone.

    I do believe if we can reduce the production of testosterone, then there will be a lot less problems during everybody's mtf.

   So far I have found out that Peony, Licorice, Progesterone, Cyproterone acetate, and Medroxyprogesterone all reduce the production of testosterone.

   If anyone knows of anything esle, please post it.

     Blessings

     Steffy Anne

Faith + Hope + Love >

Love and Joy and Peace

 

Here's my NBE plan from years ago. I'll probably update this asap reflecting any recent discoveries.

The quickest way towards feminization,

• Liver activation of protein/enzymes & hormones
  
• Growth Hormone signal via CYP2AB enzyme
  
• Increased GH (growth hormone) secretion via the hypothalamus
  
• Inhibit lutenizing hormone
  

NBE key tools

• Foods
• Lemons, oranges, red pigment fruits and veggies.....all of which inhibits CYP17 enzyme (a key enzyme in the steroid biosynthesis of androgens)
  
• Green tea-also a CYP17 inhibitor / also a CYP19 promoter (aka-aromatase)
  
• walnuts (1/4 cup) 2-3x a week, pro ER-a, antioxidant, w-6 fatty acid
  
• Drink (min) 4 cups of green tea daily (80-98% polyphenols)
  
• Drink filtered water 6-8 cups (add a slice of fresh lemon)
  
• Get 10 minutes of high intensity work outs 3-4x a week
  
• Reduce coffee (1 cup per day)
  
• Add protein and healthly fats
  
  _____________________________
  
  Supplements
  
• White peony extract (2-3 per day) pro-aromatase, 5 alpha reductase inhibitor (inhibits DHT).
  
• Red clover extract (1-2 per day)......,low progesterone effect, pro-estrogen alpha receptor promoter. pro-areolas
  
• Authentic PM 1000mg (total).....up to 250 mg for women, days 1-14 (after periods ends)........pro-estrogen mimic, activates CYP2AB enzyme (necessary for feminization)
  
  
• Progesterone cream (applied to breasts, 3-4 times per week).....progesterone
  
• L-arginine (1 per day)........amino-acid, for activation of growth hormones signaling.
  
• reishi 1-2 (per day)........anti-androgen
  
• astaxanthin (1-2 per day)......anti-androgen
  
• niacin (inositol) 1-2 per day
  
• MSM, antioxidant, pro-breast health, GH (growth hormone) STAT5 protein synthesizer.......
  
  

Green Tea - stimulates beta-receptors at fat cells to increase release of lipids into the bloodstream. why is this important?, 95-98% fatty acids are bound in the blood stream (just like hormones are), we needed something that displaces hormones and fatty acids, looks like green tea is up for the task.




To be continued..........

How well does astaxanthin work?

I feel your pain Steffy-Anne, please let me try to put your mind at ease, sincere apologies for the late response. I'm sure you remember in Bobbi's DHT thread we laid out how the steroidogenesis of Testosterone (all androgens to be exact) is cleaved through a side chain of the enzyme 17,20 lyase (meaning the biosynthesis of androgens). That's where GTE comes in, it inhibits this 17,20 lyase pathway, so how do we know this?. 

From the attached study: A complete inhibition of this enzyme would provide an alternative means of androgen suppression for the treatment of prostatic cancers. 

At issue is how long it takes to reduce T down to nothingness I think it was estimated to be 6 month, though that's subjective as everyone is different. Though say when someone comes off of long term anti-androgen therapy it takes up to a year for T to rebound...another slow process. 

The L-theanine in green tea elevates neurotransmitters in the brain..like dopamine, gaba and serotonin. And 2 pills of theanine in GTE knocks me out, lol.

 Have you had any blood work done?, I'd start there just to gauge how well your current program is doing. And absolutely get the best GTE or Matcha. 

And alternatively one could see a trans friendly doctor...preferably one who specializes in transgender care and go from there. Btw, you look very fem in your avatar...cool.

1. Where does the androgen pathway begin?, from cholesterol. We start with the cholesterol to testosterone pathways where DHT can do its damage. 

See the diagram in which 17α-hydroxylase and 17,20-lyase are located. Inhibiting this enzyme so early in the biosynthesis of androgens is real game change. 

Theres another option though, and that's by elevating SHBG (sex hormone binding globulin). And SHBG's job is to transport hormones to target tissues. So, if Estradiol is elevated in SHBG (around 120 ng/dL) time is stuck in SHBG unable to transport. SHBG originates in the liver. 

High levels of T and DHT are effective in displacing E2 (estradiol) from target tissues. When this inverse relationship of high T/DHT to Estradiol is present you can kiss feminizing...and breast growth because DHT has a 4x affinity over Estradiol in SHBG. 

Green Tea raises estradiol in SHBG...now that's something to get overly excited about?.

Higher body temp (like over 99⁰) raises SHBG and thus inhibits DHT.

Yes, green tea raises SHBG. Let's put it this way, raising SHBG raises E2 (estradiol)...other things raise SHBG too.

High insulin lowers SHBG, that'll raise testosterone and go in the wrong direction.

cAMP (cyclic adenosine monophosphate) which are second messengers will increase SHBG, I know, it's technical.

Things like metformin will increase SHBG. We've known about SHBG since 2015 here at BN. Check out this thread in the Ladies forum, it's full of good stuff. We even had a scientist (Clelia) join in with the research. Something I found out was that the receptors cells are made up of palmitic acid, and how cool is that?. This means receptor cells are fat lovin.

NBE Research
https://www.breastnexus.com/showthread.php?tid=23246

I'm still working on a list of what raises SHBG. But think about this, if we knew how to raise SHBG...it may mean taking less NBE/HRT.

I forgot to add high insulin levels lowers estradiol, making it easy for DHT to dominate SHBG, which will inhibit estradiol.

I've just seen a face I can't forget the time or place
Where we just met, she's just the girl for me
And I want all the world to see we've met
Mmm-mmm-mmm-m'mmm-mmm

Fallin', yes I am fallin'
And she keeps callin' me back again

  Thank you Lotus;

  It sure is clear that you learned a lot. Unfortunatly for me, I don't understand ANY tecnical chemistry at all.

  I can't afford doctors, or blood tests, so I gage my T by my morning wood.

  I started .5mg E2gel, 1mgE2pill, 1mgMedroxyprogesterone, and 10mg Cyproterone acetate last week, and the wood is stopped. Yay. So now I figure my E, and P can do what they are supposed to.

  My question was, are their naural suppliments that reduce Gonadal prodution of Testosterone.

   Thank you very much for your longsuffering toward me.

  Steffy Anne.

Faith + Hope + Love >

Love and Joy and Peace

Wow, look who showed up.  

Thanks for the info again, I'm starting to get my head around this stuff little by little... Making more sense into why its a good idea to eat well and ditch sugar completely.

Wow, look who showed up.  

Thanks for the info again, I'm starting to get my head around this stuff little by little... Making more sense into why its a good idea to eat well and ditch sugar completely.

Lol, I did didn't I. Eating well really does benefit breast growth. Too much sugar spikes insulin, and as a result testosterone spikes.

There was a saying some years ago about if you want bigger boobs then eat more pies, lol, it was a humorous scarcastic point, but way off point.

Wow, look who showed up.  

Thanks for the info again, I'm starting to get my head around this stuff little by little... Making more sense into why its a good idea to eat well and ditch sugar completely.

Lol, I did didn't I. Eating well really does benefit breast growth. Too much sugar spikes insulin, and as a result testosterone spikes.

There was a saying some years ago about if you want bigger boobs then eat more pies, lol, it was a humorous scarcastic point, but way off point.

It was funny btw when I got into NBE, I soon noticed that I eat a lot of beneficial foods that were listed somewhere over here.

Gonna Bump this post. Apologies but I'm working On the new Guide, either later tonight or tomorrow,  I think (hope) it addresses new issues and new tech.

Perhaps some have seen the following information on reddit(?). If not it's a compilation of breast measuring tools. Of interest to myself are two measuring techniques.

1. Breast Hemicircumference
   
2. Breast units
   

Now the hemicircumference is measured across (3 to 6 o'clock) your breasts...this gives you cup size.

The second is measured (in centimeters) from 3 to 6 o'clock and from 12 to 6 o'clock. This tool can tell you if your breasts are growing, and not just on width but horizontal too. And these two numbers are multiplied. To bad the graph doesn't show adult boobage numbers, I haven't been able to find such chart. Maybe we can make our own here?.

These are my numbers as of last week:
R 33x23=759
L 31x23=713...a difference of 46.

This measuring tool will tell you if you have asymmetry (one breast is larger or smaller than the other).

Perhaps someone would like to create a new thread for folks to share their data. And if one of their breasts are asymmetric we hopefully help overcome this with different techniques.

https://www.reddit.com/r/TransBreastTimelines/comments/f8q2w2/how_to_take_simple_breast_measurements_101/?utm_medium=android_app&utm_source=share



Don't click on the breast unit links...spam ad pops up.

diometres, thanks for the feedback, I'll catch you tomorrow.

Hi Lotus ....

I'm a little confused about this. 

You say to measure from 3-6 o’clock and from 6-12 o’clock. 
Wouldn’t that be from 3-9 o’clock and then 6-12? 
I’m confused about how to measure from 3-6 and then 6-12. 
Also, you say measuring from 3-6 gives cup size. 
In what regard? .... How?
The normal (old way) technique is to measure band 
and bust then subtract to get cup. 
I can see how this could be a better way to measure, 
but it seems like part of the equation is missing. 

Thank you