21-04-2024, 03:24 AM
Hi Eloise,
Interesting herb, I'll need to do some more research on it to be able to say how it can/and or can't work for NBE. So far it looks like it does inhibit GnRH, but also estradiol too. I'd like to find human studies too.
The herbal mixture was shown to delay vaginal opening and to downregulate serum estradiol levels as well as the expression of Kiss-1 and GnRH mRNA in the hypothalamus.
Huang Bai showed greater suppressive effect on GnRH mRNA expression than estradiol (P < 0.05). Although estradiol is known to bidirectionally regulate the GnRH secreting neuronal function according to the ovulatory cycle in females, it also decreases GnRH gene expression in GT1–7 cells [16]
The findings of in vitro study suggest that Huang Bai directly inhibits GnRH gene expression in hypothalamus and promotes GH gene and protein expression in pituitary, therefore enhancing possibility of direct actions on GnRH and GH neurosecretory system in vivo. Dose- or time-dependent analysis and further in vivo studies are needed for clear efficacy of Huang Bai on GnRH and GH system.
Effects of Huang Bai (Phellodendri Cortex) and Three Other Herbs on GnRH and GH Levels in GT1–7 and GH3 Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746385/
Interesting herb, I'll need to do some more research on it to be able to say how it can/and or can't work for NBE. So far it looks like it does inhibit GnRH, but also estradiol too. I'd like to find human studies too.
The herbal mixture was shown to delay vaginal opening and to downregulate serum estradiol levels as well as the expression of Kiss-1 and GnRH mRNA in the hypothalamus.
Huang Bai showed greater suppressive effect on GnRH mRNA expression than estradiol (P < 0.05). Although estradiol is known to bidirectionally regulate the GnRH secreting neuronal function according to the ovulatory cycle in females, it also decreases GnRH gene expression in GT1–7 cells [16]
The findings of in vitro study suggest that Huang Bai directly inhibits GnRH gene expression in hypothalamus and promotes GH gene and protein expression in pituitary, therefore enhancing possibility of direct actions on GnRH and GH neurosecretory system in vivo. Dose- or time-dependent analysis and further in vivo studies are needed for clear efficacy of Huang Bai on GnRH and GH system.
Effects of Huang Bai (Phellodendri Cortex) and Three Other Herbs on GnRH and GH Levels in GT1–7 and GH3 Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746385/