Firstly, does anybody have any experience with this or know of any thorough resources?
I'd like to make tinctures of all the various things I want to try since it greatly increases their efficacy. I was doing some research- can't find the supporting documents at the moment, but when consuming estradiol orally, 90% of it gets excreted via liver metabolism and that which remains is predominately converted into estrone. Sublingual absorption and injection, however, puts the goodies straight into the bloodstream.
I'm not sure how it works with PM, since it's different stuff and, while it can bind to estrogen receptors, we probably don't have the enzymes to metabolize it, so it probably doesn't get downgraded (though much will be lost in the liver or denatured through the digestive process).
The methodologies governing the production of tinctures and essential oils is VAST, and different techniques are going to work better for extracting different chemicals. In general, it looks like alcohol absorbs steroids (phyosterols) the best, but I don't really have a clue. Could an essential oil be even more potent? What about undiluted vinegar? Can steroids even be considered alkaloids or acidic?
Some food for thought:
Cow's butter, for example, has pure estradiol, but also a much greater amount of estrone-- if it would be possible to selectively extract one, that would be awesome (though INCREDIBLY unlikely). I think you'll either get all fat soluble steroids or none at all- but I don't really know. Estradiol is more acidic than estrone, due to the hydroxyl group, but I can't imagine it making much of a difference without a very very very particular extracting technique. That said, I don't think you can even get the estradiol in a concentrated manner without all of the other fatty acids. I was reading that they use nano-tubes to press estradiol out of butter, but that is probably outside of the scope of a homebrewer...
Edit: http://www.ncbi.nlm.nih.gov/pubmed/3160986 - Though there may be a way to promote the conversion of estrone to estradiol despite the tendency to go the other way around... though I wouldn't consider this a serious avenue to take.
I'd like to make tinctures of all the various things I want to try since it greatly increases their efficacy. I was doing some research- can't find the supporting documents at the moment, but when consuming estradiol orally, 90% of it gets excreted via liver metabolism and that which remains is predominately converted into estrone. Sublingual absorption and injection, however, puts the goodies straight into the bloodstream.
I'm not sure how it works with PM, since it's different stuff and, while it can bind to estrogen receptors, we probably don't have the enzymes to metabolize it, so it probably doesn't get downgraded (though much will be lost in the liver or denatured through the digestive process).
The methodologies governing the production of tinctures and essential oils is VAST, and different techniques are going to work better for extracting different chemicals. In general, it looks like alcohol absorbs steroids (phyosterols) the best, but I don't really have a clue. Could an essential oil be even more potent? What about undiluted vinegar? Can steroids even be considered alkaloids or acidic?
Some food for thought:
Cow's butter, for example, has pure estradiol, but also a much greater amount of estrone-- if it would be possible to selectively extract one, that would be awesome (though INCREDIBLY unlikely). I think you'll either get all fat soluble steroids or none at all- but I don't really know. Estradiol is more acidic than estrone, due to the hydroxyl group, but I can't imagine it making much of a difference without a very very very particular extracting technique. That said, I don't think you can even get the estradiol in a concentrated manner without all of the other fatty acids. I was reading that they use nano-tubes to press estradiol out of butter, but that is probably outside of the scope of a homebrewer...
Edit: http://www.ncbi.nlm.nih.gov/pubmed/3160986 - Though there may be a way to promote the conversion of estrone to estradiol despite the tendency to go the other way around... though I wouldn't consider this a serious avenue to take.