(04-05-2014, 08:13 PM)spoked451 Wrote: Yeah oral (swallowed) is how you put the biggest load on the liver. Patches are a Pain in the back side, sublingual (under the tongue) is the way to go. Some good posts off site about potency of sublingual vs. oral. One write up I saw listed potency of oral estrogens at 20-30% of the dose taken whereas sublingual was nearly 90%.
Makes me wonder if PM would follow the same model. Three times less PM for the same effect? That is if PM is processed the same way as oral estrogens are. I guess it also depends on how nasty it would be sitting under one's tongue until it was all absorbed.
I know this is an older thread and I hope everything is working great for Gorgeous Blond???
I just wanted to chime in on all of this
Ive been on lots of oral E, both sublingual and buccal (between the cheek and gum)... While that does work I agree with the OP that transdermal is a superior way to go
I have seen and felt much better overall feminization since reducing oral E and switching to the Oestrogel
I just started patches along with gel and oral but I cant see why you say "they are a pain"

I mean so far I just stick it on and pretty much forget about it as it slowly and steadily gives me a dose of pure E2 right to the blood

Whats not to like about that aside from the high cost and low dosage
As far as IM injections go this seems to me to be the best way to go and I want mine done once week to keep the E level from fluctuating too much.... My problem is finding a doc who will do it though

I WILL find on eventually though....
Another way that sounds good to me is E pellets implanted under the skin that last like three months... They are supposed to be expensive and hard to get though....
It is the 21'st century after all and its my hope that we see some better ways to do this than sucking on menopause pills and taking heart and prostate meds soon