(08-04-2023, 09:49 AM)Deadname Wrote: I would like to thank everyone who has contributed (Lotus' posts have been incredibly informative for me.)
(08-04-2023, 11:00 PM)Teddy Wrote: I believe you have taken 1000 micrograms (mcg or ug) of Vitamin D! Even then your daily amount (3000 micrograms) is much over safe limit, which is, depending on the nutritional expert or doctor you ask, 100-250 micrograms a day. The amount you wrote here, 3000 milligrams/day, would have taken you pretty fast to hospital. Vitamin D is very necessary, but too much is too much.
(01-12-2022, 02:46 AM)Lotus Wrote: Continuing the research, there's a strategy in using vitamin D3 and calcium (and actual relatable science) together in my X-thread program, along with MSM. Vitamin D3 actually increases IGF-1, so as we might worry about not getting enough IGF-1 for breast growth, taking 5,000iu to 7,000iu of vitamin D3 per day helps to increase IGF1. Which is perfectly safe limits to take within these amounts.
Vitamin D increases circulating IGF1 in adults: potential implication for the treatment of GH deficiency
Pietro Ameri et al. Eur J Endocrinol. 2013
Abstract
Objectives: Previous studies suggested that vitamin D modulates circulating IGF1. We investigated this effect in adults and its clinical relevance in the management of GH deficiency (GHD).
Design and methods: IGF1 levels were prospectively measured before and after 12 weeks of treatment with oral vitamin D3 (5000 or 7000 IU/week) vs no intervention in 39 subjects 61.9±7.9 years old. The frequency of IGF1 values ≥50th age- and sex-specific percentile in relation to vitamin D status, as determined by the concentration of 25-hydroxyvitamin D (25(OH)D), was retrospectively assessed in 69 GHD patients (57.4±16.6 years) on stable hormone replacement and with 25(OH)D and IGF1 concurrently measured.
Results: Treatment with 5000 and 7000 IU vitamin D3/week significantly raised 25(OH)D by 12.7±8.4 and 13.1±6.5 ng/ml respectively (both P<0.001 vs baseline). In the 7000 IU group, IGF1 levels also significantly increased by 31.3±36.7 ng/ml (P=0.01). Neither 25(OH)D nor IGF1 significantly varied in controls. IGF1 was ≥50th percentile more frequently in GHD patients with 25(OH)D levels ≥15 than <15 ng/ml(65.9 vs 40.0%, P<0.05). Logistic regression with adjustment for recombinant human GH (rhGH) dose, vitamin D supplements, gender, use of thyroid hormones, corticosteroids or estrogen/testosterone, and season revealed a significant positive association between ≥15 ng/ml 25(OH)D and IGF 1 ≥50th percentile (OR 4.4, 95% CI 1.0-18.8, P<0.05). A significant negative correlation between 25(OH)D concentrations and rhGH dose was found after correcting for age and IGF1 (β -0.042, P<0.01), but not after further adjusting for sex, thyroid, adrenal or gonadal replacement, and season (β -0.037, P=0.06).
Conclusions: Vitamin D increases circulating IGF1 in adults. As a result, a better vitamin D status may ease the achievement of normal IGF1 values in GHD.
Vitamin D regulates IGF1 concentrations in the liver, the main source of circulating IGF1
https://pubmed.ncbi.nlm.nih.gov/24005315/
(08-04-2023, 11:00 PM)Teddy Wrote: [unnecessary quoting removed]Hello Teddy,
Hi Deadname,
I believe you have taken 1000 micrograms (mcg or ug) of Vitamin D! Even then your daily amount (3000 umicrograms) is much over safe limit, which is, depending on the nutritional expert or doctor you ask, 100-250 micrograms a day. The amount you wrote here, 3000 milligrams/day, would have taken you pretty fast to hospital. Vitamin D is very necessary, but too much is too much.
Huge amounts of vitamin D you seem to be taking can really mess up your body over time. Also, there's no need to divide that dose to two or three times/day because it isn't eliminated very fast at all. Some say you can take 7 x daily dose once a week and the effect will be roughly same as daily taking it, because body stores it. That storage phenomena is also why huge overdoses cause problems with delay.
Hugs,
Teddy
(09-04-2023, 03:47 AM)Lotus Wrote:(08-04-2023, 09:49 AM)Deadname Wrote: I would like to thank everyone who has contributed (Lotus' posts have been incredibly informative for me.)
You're welcome, I'm glad you found the information helpful.
(08-04-2023, 11:00 PM)Teddy Wrote: I believe you have taken 1000 micrograms (mcg or ug) of Vitamin D! Even then your daily amount (3000 micrograms) is much over safe limit, which is, depending on the nutritional expert or doctor you ask, 100-250 micrograms a day. The amount you wrote here, 3000 milligrams/day, would have taken you pretty fast to hospital. Vitamin D is very necessary, but too much is too much.
Pretty sure Deadname meant to input Vitamin D3 @ 1,000 IU instead of 1,000 mg.
(01-12-2022, 02:46 AM)Lotus Wrote: Continuing the research, there's a strategy in using vitamin D3 and calcium (and actual relatable science) together in my X-thread program, along with MSM. Vitamin D3 actually increases IGF-1, so as we might worry about not getting enough IGF-1 for breast growth, taking 5,000iu to 7,000iu of vitamin D3 per day helps to increase IGF1. Which is perfectly safe limits to take within these amounts.
Vitamin D increases circulating IGF1 in adults: potential implication for the treatment of GH deficiency
Pietro Ameri et al. Eur J Endocrinol. 2013
Abstract
Objectives: Previous studies suggested that vitamin D modulates circulating IGF1. We investigated this effect in adults and its clinical relevance in the management of GH deficiency (GHD).
Design and methods: IGF1 levels were prospectively measured before and after 12 weeks of treatment with oral vitamin D3 (5000 or 7000 IU/week) vs no intervention in 39 subjects 61.9±7.9 years old. The frequency of IGF1 values ≥50th age- and sex-specific percentile in relation to vitamin D status, as determined by the concentration of 25-hydroxyvitamin D (25(OH)D), was retrospectively assessed in 69 GHD patients (57.4±16.6 years) on stable hormone replacement and with 25(OH)D and IGF1 concurrently measured.
Results: Treatment with 5000 and 7000 IU vitamin D3/week significantly raised 25(OH)D by 12.7±8.4 and 13.1±6.5 ng/ml respectively (both P<0.001 vs baseline). In the 7000 IU group, IGF1 levels also significantly increased by 31.3±36.7 ng/ml (P=0.01). Neither 25(OH)D nor IGF1 significantly varied in controls. IGF1 was ≥50th percentile more frequently in GHD patients with 25(OH)D levels ≥15 than <15 ng/ml(65.9 vs 40.0%, P<0.05). Logistic regression with adjustment for recombinant human GH (rhGH) dose, vitamin D supplements, gender, use of thyroid hormones, corticosteroids or estrogen/testosterone, and season revealed a significant positive association between ≥15 ng/ml 25(OH)D and IGF 1 ≥50th percentile (OR 4.4, 95% CI 1.0-18.8, P<0.05). A significant negative correlation between 25(OH)D concentrations and rhGH dose was found after correcting for age and IGF1 (β -0.042, P<0.01), but not after further adjusting for sex, thyroid, adrenal or gonadal replacement, and season (β -0.037, P=0.06).
Conclusions: Vitamin D increases circulating IGF1 in adults. As a result, a better vitamin D status may ease the achievement of normal IGF1 values in GHD.
Vitamin D regulates IGF1 concentrations in the liver, the main source of circulating IGF1
https://pubmed.ncbi.nlm.nih.gov/24005315/
(09-04-2023, 06:29 AM)Deadname Wrote:Hi Deadname,(08-04-2023, 11:00 PM)Teddy Wrote: [unnecessary quoting removed]Hello Teddy,
Hi Deadname,
I believe you have taken 1000 micrograms (mcg or ug) of Vitamin D! Even then your daily amount (3000 umicrograms) is much over safe limit, which is, depending on the nutritional expert or doctor you ask, 100-250 micrograms a day. The amount you wrote here, 3000 milligrams/day, would have taken you pretty fast to hospital. Vitamin D is very necessary, but too much is too much.
Huge amounts of vitamin D you seem to be taking can really mess up your body over time. Also, there's no need to divide that dose to two or three times/day because it isn't eliminated very fast at all. Some say you can take 7 x daily dose once a week and the effect will be roughly same as daily taking it, because body stores it. That storage phenomena is also why huge overdoses cause problems with delay.
Hugs,
Teddy
Thanks very much for the input. I absolutely meant micrograms, I will edit my first post to make sure there is no confusion. Do we think that a once a day dose of 3,000 mcg would be more beneficial than a 3x a day approach? If so I'd be interesting in trying it out. Morning, I'd assume to simulate getting morning sun? I am living in Canada we have a hard time with vit d in general. I am using vit d3 in gel capsules if that provides further context.
Regards,
Deadname