I have always said "listen to your body" Early effects are very slight and it is important not to get discouraged. Look for a sense of increased fatiness; I used to describe it as if my chest had been upholstered. Next, you may see a slight difference in the direction, in which, your nipples point; more to the side and they may become permanently erect. If your dose is right, it may be 4+ months, before the stage, of tenderness and knots, arrives. Learn to adjust the dose, to keep a momentum going and remember the big word PATIENCE. I have been on PM for 32 months and have reached a good 38 B cup. That may sound like slow progress, but, in truth, it is probably as fast as you want to go. A year ago, I was very self concious about my boobs and very aware that they would dictate when I would transition. Then I was on the borders of A small B and, had it not been for the fact that I spent most of my time, wearing Chef's whites, I would have been past functioning as a normal male. Now, I have a pair of boobs, that I love to bits and my fat has re-distributed, to settle below my waist. I may get clocked as male but I would look a freak as male. This is the journey you have set out on; be gratefull that it is a slow one; you need the time to cope with and adjust to, what is going on with your body and the effects this will have on your life.