Sfem,
I was very interested by your post since I have peripheral neuropathy that affects sensory, motor and autonomic functions in my legs. toes and fingers to a degree that has caused me some concern; I have always been badly coordinated but my feet are becoming so clumsy that I am worried about trips and falls (one recently badly bruised my left breast and a rib beneath - very painful as you can imagine), and I have also had gout problems in the past -I was taking allopurinol for more than 12 years and only fairly recently stopped taking it (with medical approval). Possibly as a result of heart failure back in 1999, I developed chronic venous insufficiecy in my legs leading to serious edema in my legs and feet, and the doses of diuretics taken to control the edema appear to have triggered the gout, I have also wondered whether my susceptibility to gout is related to my tendency to generate stones, first kidney stones starting about 40 years ago and for the last 30 years, bladder stones. The neuropathy first really showed up about 8 or 9 years ago, at which time I started getting unreasonably painful ulcers on my toes and legs. Although my blood sugar levels were more or less OK, I did test as having impaired glucose tolerance which must have been enough to trigger diabetic neuropathy given my already impaired peripheral ciculation. I was able to beat the ulcers with the wound healing techniques of an excellent local plastic surgeon, and control the edema with pressure socks and horse chestnut . Sorry about all this history, but my point is that all this was long before I had ever heard of PM. Since I first started PM I have been on and off it and have varied my dose, more recently on a cyclical basis, and have never noticed any effect on nor recent aggravation of the neuropathy. I will certainly keep an eye open in future for possible dose related changes. When the horse chestnut (as well of course as PM) was stopped by the hospital for a week during my recent stay there, I did note a slight and fairly shortlived subsequent recurrence of edema in my ankles. One factor which I believe may be relevant is hydration level. Mine seems to vary over the medium term in a manner and for reasons I have not been able to deduce, but which again seems unrelated to PM.
Sorry, Misty, for wandering off topic.