[spanky]

Wow, Lotus!  They are magnificent!  

(I have been more of an infrequent lurker here of late, but always enjoy the science.)

[Stevenator.]

Gotta agree they're amazing. 
I'm always in awe. 
I certainly appreciate your advice.

[BeautifulBambi]

Hi Lotus, You are a true inspiration. I wonder if You have timeline of Your wonderful breast growing?

Aw thanks Andrea, i just do my own thing and try to help others along the way with what I've learned about this crazy little thing we call love....love of boobs that is.

The pics are from last night, (laying down). I'd have to dig up the old pics from 3-4 years ago tbh, but I'll check.

Just looking at that growth I dream of being able to go all the way with growing my breast and having a very curvy female figure.

[polymorphis]

Dear Lotus,

your "photos from last night" left me speechless! Beautiful... just beautiful...

I have to admit I would like to be able to grow such beauties myself   .

Sorry for being too curious, but...

How long it have taken to grow them to current size? And what size are they right now?  

And what are the reaction of other people?

Poly

[Lotus]

[attachment=14341]

● thank you spanky, I've missed yah, how's life been treating you?. 

● stevenator , I'm glad I could help, I enjoy your pm's...and so sorry, I've been otherwise distracted by other events....I should also say that to others though too, my apologies. 

● BB, I believe the time is now!, you go and grow them boobs. 

● poly, I so appreciate your kind words, it's cool hun, (@ curious), I have to laugh when I think of your question about the reaction of others, I get looks ranging from EW to a group of old ladies smiling at me.....so strange (indeed). People around me are used to them by now, I'm ok either way, (meaning I'm used to the reactions), life's to short, right?.


● if I remember correctly?, I started NBE 5/2012, so it's been about 5 years (the NBE journey), 

● my breast size is around a D-DD(D?)


● Andrea, the attachment is about 2 years ago, and the beginning picture is breast growth during the first year. The other pics are the progression of growth ranging about 2-3 years.

[Lotus]

Back to the science:  

Methylsulfonylmethane (MSM) is a small molecule @ 94 daltons, which penetrates through skin layers. So following this idea of co-administration of prolactin plus progesterone to realize this 400% increase over E2 only, MSM (cream/lotion) seems like a great carrier. Now it's finding a prolactin cream idea to complete the sequence.....research drugs?....FG (fenugreek) is an herbal option (increases PRL), I'd use it as an oil followed by PC then MSM, (how I'd do it). 



http://press.endocrine.org/doi/10.1210/en.2003-0752?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&

Following PRL and PRLR interaction, signal transducers and activators of transcription (STATs) and Methylsulfonylmethane (MSM) 


Na+/taurocholate cotransporting polypeptide (ntcp) mediates the uptake of bile salts from plasma across the basolateral domain of the hepatocyte. We have demonstrated that ntcp expression can be induced by prolactin (PRL) and placental lactogen via the PRL receptor and signal transducers and activators of transcription (Stat)5a pathway. However, elevated levels of placental lactogen do not increase the expression of ntcp in pregnant rats. Because plasma estradiol (E2) levels are also elevated in pregnancy, we investigated the inhibitory effects of E2 on PRL-induced ntcp activation. E2 treatment inhibited the PRL-induced increase in liver ntcp mRNA to the same levels as in rats treated with E2 alone. Estrogen receptor-α (ERα) mRNA and protein expression in liver were increased 2.6-fold and 2.2-fold, respectively, in pregnancy relative to controls. In HepG2 cells, E2 repressed PRL-induced ntcp reporter gene expression in a dose-dependent manner in the presence of cotransfected ERα. The ERα antagonist ICI 182,780 reversed E2-induced repression, indicating specificity of inhibition by E2. Overexpression of coactivator p300 did not reverse the inhibitory effects of E2 and ERα. Western and gel shift analysis revealed that E2-bound ERα decreased the tyrosine phosphorylation and DNA-binding activity of Stat5a, indicating that the inhibitory effect of E2was mediated, at least in part, by interfering with PRL-mediated signal transduction. The present studies demonstrate the physiological significance of cross-talk between ERα and Stat5a in liver, in which both proteins are expressed. These data also establish a novel mechanism by which expression of ntcp, an important hepatic bile acid transporter, can be regulated by multiple hormones.

Growth hormone (GH) is regulator of bone growth and bone metabolism. GH activates several signaling pathways such as the Janus kinase (Jak)/signal transducers and activators of transcription (STAT) pathway, thereby regulating expression of genes including insulin-like growth factor (IGF)-1. GH exerts effects both directly and via IGF-1, which signals by activating the IGF-1 receptor (IGF-1R). In this study, we investigated the effects of MSM on the GH signaling via the Jak/STAT pathway in osteoblasts and the differentiation of primary bone marrow mesenchymal stem cells 
https://www.ncbi.nlm.nih.gov/pubmed/23071812

Transcription of the genes encoding both ERα (Esr1) and ERβ (Esr2) is stimulated by PRL through the Jak2–Stat5 pathway and Stat5-response elements that are located in each of the Esr promoters. 
http://www.cell.com/trends/endocrinology...0030-4.pdf

MSM stimulates the stat5 pathway, thus estrogen receptors are being stimulated by MSM.....(awesome huh?).

[tanysquirrel]

as aways, your mammaries are magnificent! I stand in boob envy :  someday I will achieve your stately breast

[Lotus]

Hey there Squirrel,

And as always (too) i love to hear your feedback... thank you. I have no doubt you'll find boob utopia soon.

[tanysquirrel]

Hee hee .. BOOBTOPIA :p

[DDs_for_me]

Boobtopia!!!!!!

Lotus you kill me!! 

~H