[Stevenator.]

I was up to .5ml of injected depo-estradiol once weekly, and still no effects. He refused to raise it higher because I am a smoker. No I am not yet ready to quit, sorry but current stress levels don't allow me to.

You'd really rather quit HRT than quit smoking?

I'm not saying it's not hard, but smoking makes E less effective. 

No one else is saying it, but that is your choice, smoking or the woman in the picture.

I took Wellbutrin for three days and quit smoking, and I’d smoked for a stretch of ten years. Three days on Wellbutrin, and I believe it shut down the dopamine receptors. My cigarette all of a sudden tasted like nothing and I had zero positive effects from that first drag. I snuffed it out, and that was 1.5 years ago.